The roles of novel pathways in the activation and regulation of the adaptive immune response in health and disease.

免疫系统旨在保护我们免受感染，疫苗利用这一点在预防许多感染方面取得了巨大成功。 然而，免疫系统也可以“失败”并在称为自身免疫的过程中攻击身体，例如破坏类风湿性关节炎的关节。这项提案将确定白色血细胞如何工作，以使更好的疫苗对感染和这些相同的免疫细胞如何可以故障，以创造自身免疫性疾病，如克罗恩病。

The immune system is designed to protect us against infection and vaccines exploit this with great success in preventing many infections. However, the immune system can also 'fail' and attack the body in a process called autoimmunity e.g. destroying joints in rheumatoid arthritis. This proposal will define how white blood cells work to make better vaccines against infection and how these same immune cells can malfunction to create autoimmune diseases like Crohn's disease.