The Role of NOD proteins in T cell development and function.

NOD 蛋白在 T 细胞发育和功能中的作用。

• 批准号: nhmrc : 1009538
• 负责人: Dr Amanda Gavin
• 金额: $ 23.31万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-nod-proteins-development-function/109420
• 关键词: Role; NOD; proteins; cell; development

The long-term goal of this project is to understand the role of NOD proteins in the T cell branch of the immune system. Distorted T cell responses can lead to over-activation and autoimmunity, or host susceptibility to microbial infection. This project aims to provide a deeper understanding of NOD proteins in chronic inflammatory diseases like Crohn’s disease, where altered NOD signaling may generate intrinsic T cell defects, in addition to altered microbial sensing and host protection by the innate immune system.

该项目的长期目标是了解NOD蛋白在免疫系统T细胞分支中的作用。扭曲的T细胞反应可导致过度活化和自身免疫，或宿主对微生物感染的易感性。该项目旨在提供对慢性炎症性疾病（如克罗恩病）中NOD蛋白的更深入了解，其中改变的NOD信号可能会产生内在的T细胞缺陷，此外还改变了先天免疫系统的微生物传感和宿主保护。