The role of ELF4 in the Arabidopsis circadian system.

ELF4 在拟南芥昼夜节律系统中的作用。

• 批准号: 0416762
• 负责人: Thomas Schultz
• 金额: $ 43.86万
• 依托单位: The Scripps Research Institute
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-10-01 至 2007-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0416762&HistoricalAwards=false
• 关键词: role; ELF4; Arabidopsis; circadian; system.

Rhythmic processes exhibiting 24 hour periodicity under constant conditions are observed in organisms spanning all major kingdoms of life. These circadian rhythms control a diverse array of physiological processes and are responsive to environmental stimuli such as light and temperature. Understanding the molecular mechanisms operating during circadian time keeping in diverse organisms is important for identifying common themes and characterizing unique features. The goal of this proposal is to determine the role of a unique protein, ELF4, in the progression of the circadian clock in Arabidopsis. Given the myriad of processes under clock control, ranging from development to biochemistry, physiology, and reproduction, developing a mechanistic understanding of how the clock regulates such a diversity of plant biology will certainly have implications in both general biology and in agriculture. Research on the circadian clock also provides a unique opportunity to integrate molecular research with whole plant physiology. In addition to its Broader Impacts on basic and applied science, the research will have an important training function and will serve as the vehicle for training graduate students and postdoctoral fellows. Underrepresented minority involvement will also be sought.

在恒定条件下，在所有主要生命领域的生物体中都观察到具有24小时周期性的节律过程。这些昼夜节律控制着一系列不同的生理过程，并对光和温度等环境刺激作出反应。了解不同生物在昼夜节律保持过程中的分子机制对于识别共同主题和表征独特特征非常重要。这项提议的目的是确定一种独特的蛋白质ELF4在拟南芥生物钟进程中的作用。考虑到生物钟控制下的无数过程，从发育到生物化学、生理学和生殖，发展对生物钟如何调节植物生物学多样性的机制理解，肯定会对普通生物学和农业产生影响。对生物钟的研究也提供了一个独特的机会，将分子研究与整个植物生理学相结合。除了对基础科学和应用科学产生更广泛的影响外，这项研究还将具有重要的培训功能，并将作为培养研究生和博士后的工具。还将寻求代表性不足的少数民族的参与。