Patient-Specific Mathematical Models of the Heart for Simulation-Based Medical Planning

用于基于模拟的医疗规划的患者特定心脏数学模型

• 批准号: 0417446
• 负责人: Thomas J Hughes
• 金额: $ 7.5万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0417446&HistoricalAwards=false
• 关键词: Patient; Specific; Mathematical; Models; Heart

Patient-Specific Mathematical Models of the Heart for Simulation-Based Medical PlanningThomas J. R. Hughes, Principal InvestigatorThe University of Texas at AustinAbstractThe proposed research will endeavor to create the first patient-specific, computational models of the human heart. The models will constitute the first step in the process of "predictive medicine," in which interventions are planned, analyzed and optimized, based on predicted outcomes analogous to the design process of modern engineering. Intellectual MeritThe research will require the synthesis of state-of-the-art methodologies and development of new procedures in medical imaging data acquisition, solid modeling, mesh generation, valve modeling, and simulation. Broader ImpactThe ultimate goal of the research is to provide cardiologists and cardiovascular surgeons with vastly improved technologies to treat cardiovascular disease, resulting in lower morbidity and mortality, reduced re-operative rates, and lessened post-operative recovery time.

用于基于模拟的医疗计划的患者特定的心脏数学模型德克萨斯大学奥斯汀分校首席研究员托马斯·J·R·休斯摘要拟议的研究将努力创建第一个患者特定的人类心脏计算模型。这些模型将构成“预测医学”过程的第一步，即根据类似于现代工程设计过程的预测结果，对干预措施进行规划、分析和优化。智力价值这项研究将需要在医学成像数据采集、实体建模、网格生成、瓣膜建模和模拟方面综合最先进的方法和开发新的程序。更广泛的影响这项研究的最终目标是为心脏病学家和心血管外科医生提供大大改进的治疗心血管疾病的技术，从而降低发病率和死亡率，减少再手术率，并缩短术后恢复时间。