SBIR Phase I: Efficient Production of Broad Spectrum, Salt Tolerant, Antimicrobial Peptides for Controlling Diseases in Finfish and Shrimp Culture

SBIR 第一阶段：高效生产广谱、耐盐抗菌肽，用于控制鱼类和虾类养殖疾病

• 批准号: 0420028
• 负责人: Jon VanOlst
• 金额: $ 10万
• 依托单位: KENT SEATECH CORPORATION
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0420028&HistoricalAwards=false
• 关键词: SBIR; Phase; Efficient; Production; Broad

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a cost effective method for the synthesis and purification of antimicrobial peptides (AMP) that can be used to combat bacterial and viral diseases in aquaculture systems. The commercial application of this project will be significant in the area of aquaculture in light of a lack of effective disease treatments that are currently available. The discovery that fish and invertebrates themselves produce potent, broad-spectrum, AMPs may allow safer alternatives to chemical antibiotics for controlling diseases. High efficiency, low-cost, production of AMPs, coupled with their unique mode of killing action, may also allow development and application of new classes of natural antibiotics.

该小型企业创新研究（SBIR）第一阶段项目旨在开发一种具有成本效益的方法，用于合成和纯化可用于对抗水产养殖系统中细菌和病毒疾病的抗菌肽（AMP）。 鉴于目前缺乏有效的疾病治疗方法，该项目的商业应用将在水产养殖领域具有重要意义。鱼类和无脊椎动物本身产生强效、广谱抗菌肽的发现，可能会为控制疾病提供化学抗生素的更安全的替代品。 AMP的高效、低成本生产，加上其独特的杀伤作用模式，也可能允许开发和应用新类别的天然抗生素。