SBIR Phase I: Efficient Production of Broad Spectrum, Salt Tolerant, Antimicrobial Peptides for Controlling Diseases in Finfish and Shrimp Culture

该小企业创新研究（SBIR）第一阶段项目建议开发一种具有成本效益的方法来合成和纯化抗菌肽（AMP），该抗菌肽可用于对抗水产养殖系统中的细菌和病毒疾病。鉴于目前缺乏有效的疾病治疗方法，该项目的商业应用在水产养殖领域将具有重要意义。鱼类和无脊椎动物本身能产生强效的广谱抗菌肽，这一发现可能为控制疾病提供比化学抗生素更安全的替代品。高效率、低成本的抗菌肽生产，加上其独特的杀伤作用模式，也可能使新型天然抗生素的开发和应用成为可能。

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a cost effective method for the synthesis and purification of antimicrobial peptides (AMP) that can be used to combat bacterial and viral diseases in aquaculture systems. The commercial application of this project will be significant in the area of aquaculture in light of a lack of effective disease treatments that are currently available. The discovery that fish and invertebrates themselves produce potent, broad-spectrum, AMPs may allow safer alternatives to chemical antibiotics for controlling diseases. High efficiency, low-cost, production of AMPs, coupled with their unique mode of killing action, may also allow development and application of new classes of natural antibiotics.