Acquisition of a High-Field Multi-Nuclear FT-NMR Instrument

购置高场多核 FT-NMR 仪器

• 批准号: 0420615
• 负责人: Michael Groziak
• 金额: $ 42.66万
• 依托单位: California State University, East Bay Foundation, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0420615&HistoricalAwards=false
• 关键词: Acquisition; Field; Multi; Nuclear; FT

A grant has been awarded to California State University-Hayward under the direction of Dr. Michael P. Groziak for support of a compact, high-field (400 MHz), multi-nuclear Fourier Transform Nuclear Magnetic Resonance (FT-NMR) instrument system. A core group of four active researcher-educators will manage this NMR instrument system, conducting their own research dependent upon hands-on access to just such equipment and helping other researchers both on and off campus with NMR-related research. The instrument being acquired is the most compact on the market, and it is equipped with a computer workstation, state-of-the art software, and various probes for recording signals from many different nuclei in the periodic table.The core users have set up their research laboratories, they have attracted students to their groups, and they have already obtained external funding for research in areas traditionally supported by the NSF. The focus of their investigations is in the fields of bio-organic and biophysical chemistries, where they are poised to advance scientific knowledge and understanding. Specifically, they will be studying viral membrane proteins and nucleic acids, new boron heterocycles and tethered nucleotides, enzyme inhibitors, the interaction of small molecules with artificial membrane systems, and metabolites of cytochrome P450 oxidation of organic contaminants. The instrument will be integrated into the Department's teaching curriculum for the purpose of training young researchers. The results of all of these research-centered efforts will be broadly disseminated in meeting presentations and scientific publications, and they will be highlighted on the Department's Web site. Because of their prior extensive experience with this type of instrument, the core users group is well qualified to maintain it and to use it to its full capacity to support their research efforts and those of others.California State University-Hayward is one of the last few remaining in the CSU system to obtain this type of modern NMR instrument. It is an Undergraduate Research Institution ranking 39th in the nation for granting baccalaureate degrees to minority students. The presence of this instrument on campus will stimulate an enhanced interest among a large number of minority and female students to pursue research activities and degrees in the chemical sciences and related fields. This expectation is supported by the Department's graduating student track record, its ongoing participation in several highly successful minority research programs, and by the student composition of the University as a whole. The instrument will have an immediate and deliberate impact upon many of the Department's research training-focused laboratory courses, thus providing even more encouragement for students to become involved in NMR-related research activities as upperclassmen. Finally, it will have a significant impact upon the larger society as a whole. In particular, the community colleges in the immediate vicinity of CSU-Hayward will be well served by the core users when they run spectra, hold workshop training sessions, present seminars, and provide access to this modern research instrument.

在Michael P. Groziak博士的指导下，加州州立大学海沃德分校获得了一笔赠款，用于支持一个紧凑、高场（400 MHz）、多核傅里叶变换核磁共振（FT-NMR）仪器系统。一个由四名活跃的研究人员和教育工作者组成的核心小组将管理这个NMR仪器系统，根据实际操作来进行自己的研究，并帮助校内和校外的其他研究人员进行NMR相关的研究。这台仪器是市场上最紧凑的仪器，配备了计算机工作站、最先进的软件和各种探头，用于记录周期表中许多不同核的信号。核心用户建立了自己的研究实验室，吸引了学生加入他们的小组，他们已经获得了NSF传统支持的研究领域的外部资金。 他们的研究重点是在生物有机和生物物理化学领域，在那里他们准备推进科学知识和理解。 具体来说，他们将研究病毒膜蛋白和核酸，新的硼杂环和束缚核苷酸，酶抑制剂，小分子与人工膜系统的相互作用，以及细胞色素P450氧化有机污染物的代谢产物。该仪器将被纳入该部的教学课程，以培训年轻的研究人员。所有这些以研究为中心的努力的结果将在会议介绍和科学出版物中广泛传播，并将在该部的网址上突出显示。 由于他们以前对这种类型的仪器有着丰富的经验，核心用户组完全有资格维护它，并充分利用它来支持他们和其他人的研究工作。加州州立大学海沃德分校是CSU系统中最后几个获得这种现代核磁共振仪器的人之一。它是一所本科研究机构，在全国排名第39位，为少数民族学生授予学士学位。这一仪器在校园的存在将激发大量少数民族学生和女学生在化学科学和相关领域从事研究活动和攻读学位的兴趣。 这一期望得到了该部门毕业生的成绩记录，其在几个非常成功的少数民族研究项目的持续参与，以及整个大学的学生组成的支持。 该仪器将对许多部门的研究培训为重点的实验室课程产生直接和故意的影响，从而为学生提供更多的鼓励，成为高年级学生参与NMR相关的研究活动。 最后，它将对整个社会产生重大影响。 特别是，社区学院在邻近的CSU海沃德将很好地服务于核心用户时，他们运行光谱，举办讲习班培训课程，目前的研讨会，并提供访问这一现代化的研究工具。