Computational modelling of the binaural coincidence detector circuit (B01)

内侧上橄榄核(MSO)神经元的放电频率对耳间时间差(ITD)的变化非常敏感，而ITD是人类声源在方位平面上定位的最重要线索。在之前的资助时期，我们专注于MSO神经细胞膜的模型，以解释快速突触输入和动作电位产生的整合。我们现在利用这些结果来开发一个MSO神经元群体的现象学模型，以评估关于这个核如何在复杂的声学环境中代表方位空间的不同假设。我们还将与CRC合作伙伴合作，模拟听觉脑干中的轴突传导。

The firing rate of the neurons in the medial superior olive (MSO) is sensitive to changes as small as ten microseconds in interaural time difference (ITD), the most important cue for sound source localization in the azimuthal plane in humans. In the previous funding periods we were focusing on models of the MSO nerve cell membrane to explain integration of fast synaptic inputs and action potential generation. We now use these results to develop a phenomenological model of the population of MSO neurons to evaluate different hypotheses on how this nucleus represents azimuthal space in complex acoustic environments. We will also collaborate with CRC partners on modelling axonal conduction in the auditory brainstem.