The Southern California Genotyping Consortium

南加州基因分型联盟

• 批准号: 0431977
• 负责人: Nelson Freimer
• 金额: --
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0431977&HistoricalAwards=false
• 关键词: Southern; California; Genotyping; Consortium

This award provides partial support for the acquisition of a bead-based genotyping instrument. The instrument will permit high throughput, low cost genotyping of single nucleotide polymorphisms (SNPs) by a consortium of users at several Southern California institutions, including: UCLA, UC Irvine, UC San Diego, and the University of Southern California. The system will be used for genome-wide association studies and intensive study of selected genome regions in numerous populations and different organisms. Projects that will benefit from the acquisition include: (1) determining if linkage disequilibrium mapping can be used as an extremely efficient method for understanding the molecular basis of variation in plants, (2) development of general methods for improving cultivated crops, (3) understanding wing eyespot patterning in butterflies, (4) dissecting postzygotic isolation in copepods, (5) characterizing economically important oysters, and (6) mammalian conservation efforts.

该奖项为获得基于珠粒的基因分型仪器提供了部分支持。 该仪器将允许由南加州几个机构的用户组成的联盟对单核苷酸多态性（SNP）进行高通量、低成本的基因分型，这些机构包括：UCLA、UC Irvine、UC San Diego和南加州大学。 该系统将用于全基因组关联研究，并对许多种群和不同生物体中的选定基因组区域进行深入研究。 将从收购中受益的项目包括：（1）确定连锁不平衡作图是否可以用作理解植物变异的分子基础的极其有效的方法，（2）开发改进栽培作物的一般方法，（3）理解蝴蝶的翅眼斑图案，（4）解剖桡足类的合子后隔离，（5）描述经济上重要的牡蛎，（6）哺乳动物保护工作。