An Integrative and Interactive Approach for Co-estimation of Multiple Sequence Alignment and Phylogeny Reconstruction

多序列比对和系统发育重建共同估计的综合交互式方法

• 批准号: DP0985271
• 负责人: A/Prof Bing Zhou
• 金额: $ 13.49万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-03-02 至 2014-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0985271
• 关键词: Integrative; Interactive; Approach; Co; estimation

In this project innovative IT methods will be developed to assist biologists to solve complex and important biological problems. Many important applications in computational biology need very accurate and reliable tools for multiple sequence alignment and phylogeny reconstruction. Unfortunately, current existing tools are unreliable and are prone to serious errors when applied to large and divergent biological sequences. The success of this project will not only make significant contribution to the relevant research fields, but also help achieve goals in certain real-life biological research projects which are unique and important to Australia.

在这个项目中，将开发创新的IT方法来帮助生物学家解决复杂和重要的生物学问题。计算生物学中的许多重要应用都需要非常准确和可靠的工具来进行多序列比对和系统发育重建。不幸的是，现有的工具不可靠，当应用于大的和不同的生物序列时容易出现严重的错误。该项目的成功不仅将对相关研究领域做出重大贡献，还将有助于实现某些现实生活中的生物研究项目的目标，这些项目对澳大利亚来说是独特和重要的。