Center for Subtropical and Tropical Oceans and Human Health Research in the Marine Sciences

海洋科学研究中心亚热带和热带海洋与​​人类健康研究中心

• 批准号: 0432368
• 负责人: Lora Fleming
• 金额: --
• 依托单位: University of Miami
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0432368&HistoricalAwards=false
• 关键词: Center; Subtropical; Tropical; Oceans; Human

ABSTRACT OCE-0432368NSF-NIEHS Research Center of Excellence in Oceans and Human Health at the University of MiamiOver the past decade, there has been increasing recognition that the ocean and the ocean-land interface are the sources of organisms and chemicals that can profoundly affect human health. The incidence of harmful algal blooms (HABs) that contaminate the food web or become aerosolized and cause respiratory disease, for example, seem to be increasing in coastal waters worldwide. Coupled with the increasing degradation of coastal waters is the fact human populations inhabiting coastal areas are growing rapidly via migration and reproduction; these two coincident characteristics have resulted in new public awareness and concern for the coastal marine environment.With support for this Center, researchers at the University of Miami will concentrate attention on HAB-related research in the subtropical and tropical oceans adjacent or near Florida. In order to create an environment of inquiry in which oceanographic investigators and biomedical scientists are engaged in fully collaborative research, each research project at the Center will have two principal investigators, an oceanographer and a biomedical researcher. Overall, the University of Miami's Center for Subtropical and Tropical Oceans and Human Health Research in the Marine Sciences (CSTORMS) will include three Research Projects and three Core Facilities. The three Research Projects, known as Recreational Microbes (Assessment of Microbial Indicators for Monitoring Recreational Water Quality in Marine Subtropical and Tropical Environments), Toxic HABs (Toxic Algae: a General Phenomenon in Subtropical and Tropical Coastal Waters and Open Ocean Environments?), and HAB Functional Genomics (Functional Genomics of a Subtropical Harmful Algal Bloom Species: Karenia brevis Davis) are the subject of this NSF proposal. The three Facilities Cores, known as Genomics, Remote Sensing and Toxic Algal Culture, will support the research projects and are funded by NIEHS.Recreational Microbes will investigate the present use of microbial indicators of human health effects in subtropical recreational marine waters, incorporating ongoing modeling of the physical oceanographic environment with the addition of characteristics of microbes causing or indicating public health problems on beaches. This collaboration of environmental engineers, remote sensing oceanographers, microbiologists, physical oceanographic modelers and epidemiologists hope to discover basic, predictive indicators of coastal contamination, including residence times and transport pathways of microbes. Toxic HABs will expand existing research into Harmful Algal Blooms (HABs) being conducted by the NIEHS Marine and Freshwater Biomedical Sciences Center and the NIEHS-funded Florida International University (FIU)-University of Miami (UM) ARCH Program to study population dynamics of phytoplankton species at low concentrations. Many species of dinoflagellates, cyanobacteria and other algae produce toxins that are not presently noticed by humans because those species are not dense enough to produce harmful quantities of toxins or because they are in areas of the ocean where humans are not exposed to the toxins. To better understand the molecular mechanisms and population dynamics that produce toxins, HAB Functional Genomics will investigate mRNA expression in Karenia brevis populations in bloom and non-bloom conditions in the field, quantify patterns of gene expression in K. brevis cultures exposed to different environmental conditions, and use genetic markers to describe population divergence among blooms in the field. An Administrative Office will encourage integrated interdisciplinary and inter-institutional collaboration through an outreach and education, and will be supported by Internal and External Advisory Committees.Broader Impacts: The broader goals of CSTORMS are to foster innovative interdisciplinary scientific research of importance to human health, and to train scientists in the biological and oceanographic sciences concerning issues affecting the subtropical and tropical oceans, and their associated human populations. To accomplish its research program in subtropical/tropical oceans and human health, CSTORMS will collaborate with interdisciplinary scientists at Florida International University (FIU) (Miami, FL), the Centers for Disease Control and Prevention (CDC) (Atlanta, GA), the Miami Dade County Dept of Health (Miami, FL), the University of Florida (Gainesville, FL), and other institutions, as well as other Oceans and Human Health Centers.

摘要OCE-0432368NSF-NIEHS研究中心在过去十年中，迈阿密大学的海洋与人类健康卓越研究中心，人们越来越认识到海洋和海洋界面是可以对人类健康产生深远影响的生物和化学物质的来源。 例如，在全球沿海水域中，有害藻类开花（HAB）的发生率似乎正在污染食物网或被雾化并引起呼吸系统疾病。 再加上沿海水域的下降，居住在沿海地区的人口正在通过迁移和繁殖迅速增长。这两个一致的特征引起了新的公众意识和对沿海海洋环境的关注。在对该中心的支持下，迈阿密大学的研究人员将集中精力关注与HAB相关的研究，在邻近或佛罗里达州附近的亚热带和热带海洋中。 为了创造一个探究环境，海洋学研究人员和生物医学科学家都从事完全协作的研究，该中心的每个研究项目都将有两名主要研究人员，一名海洋学家和一名生物医学研究人员。 总体而言，迈阿密大学亚热带和热带海洋和人类健康研究中心（CSTORMS）将包括三个研究项目和三个核心设施。 这三个研究项目，称为休闲微生物（评估海洋亚热带和热带环境中休闲水质的微生物指标），有毒HAB（有毒藻类：亚热带和热带沿海水域中的一般现象：一种一般现象Brevis Davis）是该NSF提案的主题。 这三个设施核心，称为基因组学，遥感和有毒的藻类培养物将支持研究项目，并由NIEHS。RECREATIONTIRATIONMICROBES研究，在亚热带休闲海水中，人类健康效应的微生物指标目前的使用指标在沿海的海洋环境中融合了远离野生动物的物理模型，或者在海滩上融合了越来越多的疾病。 环境工程师，遥感海洋学家，微生物学家，物理海洋学建模者和流行病学家的这种合作希望发现沿海污染的基本，预测指标，包括微生物的停留时间和运输途径。 有毒HAB将将现有研究扩展到NIEHS海洋和淡水生物医学中心进行的有害藻华（HAB），以及NIEHS资助的佛罗里达国际大学（FIU） - 迈阿密（UM）拱门计划，以研究低浓度的Phytoplankton种群的人群动力学。 许多种类的鞭毛藻，蓝细菌和其他藻类会产生人类目前未注意的毒素，因为这些物种的密集不足以产生有害的毒素，或者因为它们在人类不暴露于毒素的海洋地区。 为了更好地理解产生毒素的分子机制和种群动力学，HAB功能基因组学将研究Brevis Brevis种群中的mRNA表达，在该领域的盛开和非散布条件下，量化了Brevis培养物中基因表达的模式。 An Administrative Office will encourage integrated interdisciplinary and inter-institutional collaboration through an outreach and education, and will be supported by Internal and External Advisory Committees.Broader Impacts: The broader goals of CSTORMS are to foster innovative interdisciplinary scientific research of importance to human health, and to train scientists in the biological and oceanographic sciences concerning issues affecting the subtropical and tropical oceans, and their associated human人群。 为了完成其亚热带/热带海洋和人类健康研究计划，CSTORS将与佛罗里达国际大学（FIU）（FIU​​）（佛罗里达州迈阿密），疾病控制与预防中心（CDC）（佐治亚州亚特兰大）（佐治亚州亚特兰大）（乔治亚州亚特兰大），迈阿密·达德·达德县（Miami dade County）的卫生局（迈阿密县）（佛罗里达州）（佛罗里达州）（GANEES VIRLES，GANEES，GANEES，GANEES，GANEES，GANEES，GAINES，GAINES，GAINES，GAINES，GAINES），将与佛罗里达国际大学（FIU）（FIU​​）的跨学科科学家合作，海洋和人类健康中心。