U.S.-Argentina Collaborative Research: Thermal Stability of Thermophilic Membrane Proteins

美国-阿根廷合作研究：嗜热膜蛋白的热稳定性

• 批准号: 0436435
• 负责人: Jose Arguello
• 金额: $ 2万
• 依托单位: Worcester Polytechnic Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2008-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0436435&HistoricalAwards=false
• 关键词: U.S.; Argentina; Collaborative; Research; Thermal

0436435ArguelloThis U.S.-Argentina award will provide support for collaborative research between Dr. Jose M. Arguello, Worcester Polytechnic Institute, and Dr. Francisco L. Gonzalez-Flecha at the University of Buenos Aires in Argentina. They will study P-type ATPases, an important class of membrane proteins, from theromophilic organisms. The results of this work will increase our understanding of this type of protein, which is one of the most important membrane proteins, but experimentally difficult. Each side of this international collaboration brings unique expertise to the project. The U.S. lab will provide strains and the experimental approach to express heterologous Cop A, an experimental system that is not yet broadly developed in Argentina. Dr. Gonzalez-Flecha will bring his expertise on physical-chemistry for the study/analysis of membrane proteins.

0436435 ArguelloThis美国-阿根廷奖将为何塞M。伍斯特理工学院的Arguello博士和弗朗西斯科L. Gonzalez-Flecha在阿根廷布宜诺斯艾利斯大学。 他们将研究P型ATP酶，这是一类重要的膜蛋白，来自嗜热生物。 这项工作的结果将增加我们对这类蛋白质的了解，这是最重要的膜蛋白之一，但实验困难。 这种国际合作的每一方都为该项目带来了独特的专业知识。 美国实验室将提供菌株和实验方法来表达异源Cop A，这是一种尚未在阿根廷广泛开发的实验系统。 Gonzalez-Flecha博士将把他在物理化学方面的专业知识用于膜蛋白的研究/分析。