U.S.-Japan Cooperative Research: Dynamical Foundation of Protein Function: Energy Transfer and Storage

美日合作研究：蛋白质功能的动态基础：能量转移和储存

• 批准号: 0437165
• 负责人: David Leitner
• 金额: --
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0437165&HistoricalAwards=false
• 关键词: U.S.; Japan; Cooperative; Research; Dynamical

0437165LeitnerThis award supports a two-year collaborative research project between Professor David Leitner of the University of Nevada in Reno and Professor Tamiki Komatsuzaki at Kobe University in Japan. They will be undertaking a study on the dynamical foundation of protein function with reference to energy transfer and storage. The proposal details a number of interconnected collaborative projects planned by three U.S. research groups and four research groups in Japan with the goal of providing a molecular-level description of energy transport and storage in proteins. Each group is presently involved in theoretical and computational studies of energy transport in proteins and protein dynamics during function and folding. The three goals of the proposal will address, through computational modeling, the following: 1) energy flow in proteins, with emphasis on elucidation of pathways and the role of protein structure; 2) the influence of both aqueous and non-aqueous environments on energy flow and storage in proteins; and 3) analysis of non-Brownian dynamics of proteins over many time scales, with particular focus on the properties of the potential energy landscape that give rise to complex dynamics. This project brings together the efforts of a number of laboratories that have complementary expertise and research capabilities. Both groups have expertise in theoretical and computational chemistry and biology. Through the exchange of ideas and technology, this project will broaden our base of basic knowledge and promote international understanding and cooperation. The project includes the participation of postdocs and graduate students. Results of the research will be disseminated at scientific meetings and in scientific journals.

该奖项支持里诺内华达大学的大卫·莱特纳教授和日本神户大学的小崎达美教授之间为期两年的合作研究项目。他们将进行一项关于蛋白质功能的动力学基础的研究，涉及能量转移和储存。该提案详细介绍了由三个美国研究小组和四个日本研究小组计划的多个相互关联的合作项目，目标是提供对蛋白质中能量运输和储存的分子水平描述。目前，每个小组都参与了蛋白质能量传输的理论和计算研究，以及蛋白质在功能和折叠过程中的动力学。该提案的三个目标将通过计算模型解决以下问题：1)蛋白质中的能量流动，重点是阐明途径和蛋白质结构的作用；2)水和非水环境对蛋白质中能量流动和储存的影响；以及3)分析蛋白质在许多时间尺度上的非布朗动力学，特别是引起复杂动力学的势能图景的性质。该项目汇集了多个具有互补专业知识和研究能力的实验室的努力。这两个小组都拥有理论、计算化学和生物学方面的专业知识。通过思想和技术的交流，这个项目将扩大我们的基础知识基础，促进国际理解与合作。该项目包括博士后和研究生的参与。研究结果将在科学会议和科学期刊上传播。