Operational Support for the Ambystoma Genetic Stock Center

为 Ambystoma 遗传库存中心提供运营支持

• 批准号: 0443496
• 负责人: Stephen Voss
• 金额: $ 99.01万
• 依托单位: University of Kentucky Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2010-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0443496&HistoricalAwards=false
• 关键词: Operational; Support; Ambystoma; Genetic; Stock

This award provides support for the move of a living collection of Ambystoma mexicanum, commonly called the axlotyl, from Indiana University (IU) to the University of Kentucky (UKY). The award will also support continued operation of the collection once the move is completed in the summer of 2005. The collection, originally established many decades ago at IU, is a historically significant resource that provides animals used actively and widely in biological research. The recent and ongoing development of genome resources for the axolotl and other closely related species is expected to foster continued interest in Ambystoma as a powerful nonmammalian vertebrate model system. Most notably, axolotls are studied because they are unique among vertebrates in being able to perfectly regenerate numerous body parts. These include the spinal cord, limbs, jaw, and tail, all of which can be regenerated at any point during embryonic, larval, and adult life. Relocation of the collection to the UKY will consolidate the living stock resource with genome and bioinformatics resources currently being developed for the Ambystoma research community. The collection will not only continue to enable traditional research areas where the axolotl is the best vertebrate model system, it will also continue to take an active role in facilitating use of the organism in K-12 education and public outreach efforts.

该奖项为将墨西哥钝口螈（通常称为 axlotyl）活体收藏品从印第安纳大学 (IU) 转移到肯塔基大学 (UKY) 提供支持。 该奖项还将在 2005 年夏季搬迁完成后支持该馆藏的继续运营。该馆藏最初于数十年前在印第安纳大学建立，是一项具有重要历史意义的资源，提供了在生物研究中积极且广泛使用的动物。最近对蝾螈和其他密切相关物种的基因组资源的持续开发预计将激发人们对钝口蝾螈作为强大的非哺乳动物脊椎动物模型系统的持续兴趣。 最值得注意的是，蝾螈之所以受到研究，是因为它们在脊椎动物中是独一无二的，能够完美地再生许多身体部位。 这些包括脊髓、四肢、下巴和尾巴，所有这些都可以在胚胎、幼虫和成虫生命的任何阶段再生。将藏品迁至英国伦敦将整合活畜资源以及目前正在为 Ambystoma 研究界开发的基因组和生物信息学资源。该馆藏不仅将继续为蝾螈作为最佳脊椎动物模型系统的传统研究领域提供支持，还将继续在促进该生物体在 K-12 教育和公共宣传工作中的使用方面发挥积极作用。