LSCBR: Operational Support for the Ambystoma Genetic Stock Center

LSCBR：Ambystoma 遗传库存中心的运营支持

• 批准号: 0951484
• 负责人: Stephen Voss
• 金额: $ 105.52万
• 依托单位: University of Kentucky Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0951484&HistoricalAwards=false
• 关键词: LSCBR; Operational; Support; Ambystoma; Genetic

This award will support continued operation of the living collection of Ambystoma mexicanum, commonly called the axlotyl at the University of Kentucky. The collection, originally established many decades ago at IU, is a historically significant resource that provides animals used actively and widely in biological research. The ongoing development of genome resources for the axolotl and other closely related species is expected to foster continued interest in Ambystoma as a powerful non mammalian vertebrate model system. Most notably, axolotls are studied because they are unique among vertebrates in being able to perfectly regenerate numerous body parts. These include the spinal cord, limbs, jaw, and tail, all of which can be regenerated at any point during embryonic, larval, and adult life. Relocation of the collection to the UKY will consolidate the living stock resource with genome and bioinformatics resources currently being developed for the Ambystoma research community. The collection will not only continue to enable traditional research areas where the axolotl is the best vertebrate model system, it will also continue to take an active role in facilitating use of the organism in K-12 education and public outreach efforts.

该奖项将支持继续运作的生活收集Ambystoma墨西哥，通常被称为axlotyl在肯塔基州大学。该系列最初于几十年前在IU建立，是一个具有历史意义的资源，提供了在生物研究中积极和广泛使用的动物。蝾螈和其他密切相关物种的基因组资源的持续开发，预计将促进钝口螈作为一个强大的非哺乳动物脊椎动物模型系统的持续兴趣。最值得注意的是，蝾螈被研究是因为它们在脊椎动物中是独一无二的，能够完美地再生许多身体部位。这些包括脊髓，四肢，下巴和尾巴，所有这些都可以在胚胎，幼虫和成年生活中的任何时候再生。将收藏品搬迁到英国将巩固目前正在为Ambystoma研究社区开发的基因组和生物信息学资源的活种群资源。该系列不仅将继续支持蝾螈是最佳脊椎动物模型系统的传统研究领域，还将继续在促进K-12教育和公共宣传工作中使用该生物体方面发挥积极作用。