RUI: Mechanism and Kinetics of Oxidation of Guanosine Derivatives by Pt(IV) Complexes

RUI：Pt(IV) 配合物氧化鸟苷衍生物的机理和动力学

• 批准号: 0450060
• 负责人: Sunhee Choi
• 金额: --
• 依托单位: Middlebury College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0450060&HistoricalAwards=false
• 关键词: RUI; Mechanism; Kinetics; Oxidation; Guanosine

Professor Sunhee Choi of the Chemistry Department at Middlebury College is supported by the Inorganic, Bioinorganic and Organometallic Chemistry program for her bioinorganic chemistry studies on the mechanism and kinetics of the oxidation of guanosine derivatives by Pt(IV) complexes, complexes related to biologically important anticancer agents. Various Pt(IV) complexes will be synthesized and characterized. UV-visible spectroscopy, 1H and 31P NMR, HPLC and mass spectroscopy will be used to determine how the reduction potentials of Pt(IV) complexes affect the redox kinetics. Results of these studies will enhance the basic understanding of transition metal/DNA chemistry. This research will focus on the bioinorganic chemistry studies on the mechanism and kinetics of the oxidation of guanosine derivatives by Pt(IV) complexes. Platinum coordination complexes are biologically important anticancer agents. These bioinorganic chemistry studies will provide molecular level understanding of the oxidation of DNA by Pt(IV) species and enhance the basic understanding of transition metal/DNA chemistry. Undergraduate students will receive multifaceted training in inorganic synthesis and characterization and the use of transition metal complexes in probing nucleic acid toxicology, and pharmacology.

Middlebury College化学系的Sunhee Choi教授获得了无机，生物无机和有机化学计划的支持，她对Pt（IV）络合物氧化鸟苷衍生物的机制和动力学进行了生物无机化学研究，该络合物与生物重要的抗癌药物有关。 各种Pt（IV）配合物将被合成和表征。 紫外-可见光谱，1H和31 P NMR，HPLC和质谱将用于确定Pt（IV）络合物的还原电位如何影响氧化还原动力学。 这些研究的结果将加强对过渡金属/DNA化学的基本理解。本论文主要从生物无机化学的角度研究铂（IV）配合物氧化鸟苷衍生物的反应机理和动力学。 铂配合物是一种重要的抗癌药物。这些生物无机化学的研究将提供分子水平的理解氧化的DNA由Pt（IV）物种，并提高过渡金属/DNA化学的基本理解。 本科生将接受无机合成和表征以及过渡金属络合物在探测核酸毒理学和药理学方面的多方面培训。