RUI: Oxidation of Purine Derivatives Coordinated to Pt(IV) and Ru(III) Complexes

RUI：与 Pt(IV) 和 Ru(III) 配合物配位的嘌呤衍生物的氧化

• 批准号: 0848072
• 负责人: Sunhee Choi
• 金额: $ 21万
• 依托单位: Middlebury College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848072&HistoricalAwards=false
• 关键词: RUI; Oxidation; Purine; Derivatives; Coordinated

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research of Professor Sunhee Choi of Middlebury College to examine oxidation of guanine and guanine-containing nucleotides facilitated by platinum(IV) and ruthenium(III) complexation. The platinum and ruthenium binding to nucleobases and the reduction of Pt(IV) and Ru(III) have potential relevance to medicinal chemistry because they form the bases of a number of classes of anticancer drugs. The scientific implications of this research impact our understanding of biological and inorganic reaction mechanisms, especially as related to cell mutagenesis, carcinogenesis, aging and death. Undergraduate students are trained in the intricacies of modern research methods including experimental design and the interpretation of data.

无机，生物无机和有机化学计划支持明德学院的Sunhee Choi教授的研究，以检查铂（IV）和钌（III）络合促进鸟嘌呤和含鸟嘌呤核苷酸的氧化。 铂和钌与核碱基的结合以及Pt（IV）和Ru（III）的还原与药物化学具有潜在的相关性，因为它们形成了许多类别的抗癌药物的基础。 这项研究的科学意义影响了我们对生物和无机反应机制的理解，特别是与细胞诱变，致癌，衰老和死亡有关的机制。本科生接受现代研究方法的复杂性培训，包括实验设计和数据解释。