A High-Throughput DNA Analyzer for Comparative Population Genomics
用于比较群体基因组学的高通量 DNA 分析仪
基本信息
- 批准号:0500993
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-01 至 2008-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This award provides support to enable the purchase of a high throughput DNA analyzer, thermocycler and robotic workstation to be placed in a core microchemistry facility where it will be used and maintained by facility staff. This set of equipment is now a mainstay of research programs requiring high throughput DNA sequencing, microsatellite analysis, and single-nuculeotide polymorphism surveys. Investigators whose research and training efforts require use of the equipment will be charged using a set fee for service schedule. Placement of such equipment in a core facility fosters communication among different research groups who use the equipment leading to the sharing of ideas, information, and technical innovations. It also maximizes the use of the equipment by making the equipment available to a large number of other users from different disciplines and departments across campus. The equipment will allow the PI and her colleagues to expand their capacity for population-level analysis via enhancement of fragment analysis (e.g., microsatellite DNA), and more importantly, via single nucleotide polymorphism survey. The requested equipment will be housed in the Yale Institute for Biospheric Studies - Molecular Systematics and Conservation Genetic laboratory (YIBS - MSCG) which trains students in molecular techniques applied to environmental and organismal level questions. Since its inception, the YIBS - MSCG has trained students via research rotations, formal laboratory courses, dedicated seminars, and workshops. The equipment will enhance training by allowing students to obtain genetic information from large data sets in a time frame that is appropriate to their academic schedules, and do so within the budget available for training. It will also expose them early in their scientific life to state of the art equipment. The equipment is also expected to impact joint efforts of YIBS - MSCG with the Yale Peabody Museum in a science literacy partnership with the public school district of New Haven. Via this program, middle schools characterized by underachieving minority students from low-income families are targeted for educational outreach. The partnership, begun two years ago, plans to integrate the YIBS-MSCG laboratory as a means for offering additional opportunities for learning and hands-on training.
该奖项提供支持,使购买高通量DNA分析仪,热循环仪和机器人工作站被放置在一个核心的微量化学设施,它将使用和维护的设施工作人员。 这套设备现在是需要高通量DNA测序,微卫星分析和单核苷酸多态性调查的研究计划的支柱。研究和培训工作需要使用设备的研究者将按照服务计划收取固定费用。将这些设备放置在核心设施中,可以促进使用这些设备的不同研究小组之间的交流,从而分享想法、信息和技术创新。它还通过使设备提供给来自校园内不同学科和部门的大量其他用户,最大限度地利用设备。该设备将使PI及其同事能够通过增强片段分析(例如,微卫星DNA),更重要的是通过单核苷酸多态性调查。所要求的设备将被安置在耶鲁大学生物圈研究所-分子系统学和保护遗传实验室(YIBS-MSCG),该实验室培训学生应用于环境和生物体水平问题的分子技术。自成立以来,YIBS-MSCG通过研究轮换,正式的实验室课程,专门的研讨会和讲习班培训学生。这些设备将加强培训,使学生能够在适合其学业安排的时间内从大型数据集中获得遗传信息,并在培训预算范围内这样做。这也将使他们在科学生涯的早期接触到最先进的设备。该设备预计还将影响YIBS - MSCG与耶鲁皮博迪博物馆在与纽黑文公立学区的科学素养合作中的联合努力。通过这一方案,以来自低收入家庭的成绩不佳的少数民族学生为特点的中学成为教育推广的目标。两年前开始的合作伙伴关系计划将YIBS-MSCG实验室整合为一种提供额外学习和实践培训机会的手段。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Adalgisa Caccone其他文献
Author Correction: Improved reference genome of the arboviral vector Aedes albopictus
- DOI:
10.1186/s13059-021-02431-x - 发表时间:
2021-07-12 - 期刊:
- 影响因子:9.400
- 作者:
Umberto Palatini;Reem A. Masri;Luciano V. Cosme;Sergey Koren;Françoise Thibaud-Nissen;James K. Biedler;Flavia Krsticevic;J. Spencer Johnston;Rebecca Halbach;Jacob E. Crawford;Igor Antoshechkin;Anna-Bella Failloux;Elisa Pischedda;Michele Marconcini;Jay Ghurye;Arang Rhie;Atashi Sharma;Dmitry A. Karagodin;Jeremy Jenrette;Stephanie Gamez;Pascal Miesen;Patrick Masterson;Adalgisa Caccone;Maria V. Sharakhova;Zhijian Tu;Philippos A. Papathanos;Ronald P. Van Rij;Omar S. Akbari;Jeffrey Powell;Adam M. Phillippy;Mariangela Bonizzoni - 通讯作者:
Mariangela Bonizzoni
Biochemical divergence between cavernicolous and marine Sphaeromidae and the Mediterranean salinity crisis
- DOI:
10.1007/bf02003963 - 发表时间:
1980-01-01 - 期刊:
- 影响因子:6.200
- 作者:
V. Sbordoni;Adalgisa Caccone;Elvira De Matthaeis;Marina Cobolli Sbordoni - 通讯作者:
Marina Cobolli Sbordoni
Natural and experimental interspecific hybridization between populations ofDolichopoda cave crickets
- DOI:
10.1007/bf01944548 - 发表时间:
1982-01-01 - 期刊:
- 影响因子:6.200
- 作者:
Giuliana Allegrucci;Adalgisa Caccone;Donatella Cesaroni;Marina Cobolli Sbordoni;Elvira De Matthaeis;V. Sbordoni - 通讯作者:
V. Sbordoni
Adalgisa Caccone的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Adalgisa Caccone', 18)}}的其他基金
Collaborative Research: Adaptive and nonadaptive mechanisms of phenotypic evolution in response to urbanization
合作研究:响应城市化的表型进化的适应性和非适应性机制
- 批准号:
2017987 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Standard Grant
相似国自然基金
基于仿生非平衡态的DNA纳米机器构建及其对多种霉菌毒素高灵敏同步
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
复制蛋白A小分子抑制剂-HAMNO调控DNA损伤修复的结构及功能研究
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
基于合金@硼烯的比率型折纸电化学芯片构建及其在多种循环肿瘤DNA的超灵敏检测
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
基于 DNA 编码分子库的新型蛋白抑制剂分子胶水活性评价与机制研究
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
HMGCL通过H3K27乙酰化增强RAD52依赖的DNA损伤修复促进宫颈癌放疗抵抗的机制研究
- 批准号:JCZRLH202500546
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
替尼泊苷抑制APEX1驱动DNA损伤在治疗肺癌中的作用及机制研究
- 批准号:JCZRYB202500477
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
NEDD4泛素化调控CREB/miR-132轴诱发精子DNA碎片化在肥胖不育中的作用及机制
- 批准号:QN25H200016
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
高强度DNA杂化纳米机器人在内体膜调控和核酸药物递送中的基础研究
- 批准号:HDMZ25H300006
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
PLOD2的DNA低甲基化模式驱动内质网与线粒体代谢串扰诱导免疫微环境重塑和化疗耐药
- 批准号:KLY25H160008
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
LncRNA SNHG14调控miR-214-3p的DNA甲基化水平在支气管肺发育不良肺泡化阻滞的机制研究
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
相似海外基金
DNA genetic analyzer for molecular ecology/biology applications
用于分子生态学/生物学应用的 DNA 遗传分析仪
- 批准号:
RTI-2019-00600 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Research Tools and Instruments
On-demand DNA analyzer
按需 DNA 分析仪
- 批准号:
424041-2011 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)
POC DNA Analyzer
POC DNA分析仪
- 批准号:
421769-2011 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)
POC DNA Analyzer
POC DNA分析仪
- 批准号:
421770-2011 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)
AB3500xL DNA Analyzer for OHSU Core Facility
适用于 OHSU 核心设施的 AB3500xL DNA 分析仪
- 批准号:
8246286 - 财政年份:2012
- 资助金额:
-- - 项目类别:
MRI: Acquisition of an Applied Biosystems 3500xL DNA Analyzer for Interdisciplinary Genomics Research and Training at the University of Houston-Clear Lake
MRI:休斯敦大学克利尔湖分校购买了 Applied Biosystems 3500xL DNA 分析仪,用于跨学科基因组学研究和培训
- 批准号:
1126547 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Standard Grant
POC DNA Analyzer
POC DNA分析仪
- 批准号:
421774-2011 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)
POC DNA Analyzer
POC DNA分析仪
- 批准号:
421772-2011 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)
POC DNA Analyzer
POC DNA分析仪
- 批准号:
421773-2011 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)
POC DNA Analyzer
POC DNA分析仪
- 批准号:
421824-2011 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)