Design, Synthesis, and Photochemistry of New Ru(II) Complexes as Potential Photo-Cisplatin Analogs

作为潜在光顺铂类似物的新型 Ru(II) 配合物的设计、合成和光化学

• 批准号: 0503666
• 负责人: Claudia Turro
• 金额: $ 54.6万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0503666&HistoricalAwards=false
• 关键词: Design; Synthesis; Photochemistry; New; Ru

Professor Claudia Turro, a faculty member in the Department of Chemistry at Ohio State University, with Professor Kim Dunbar from Texas A& M University as the co-PI, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program to design metal complexes that can be photoactivated and bind to DNA. New ruthenium complexes will be developed to provide an alternative to photodynamic therapy agents that generate singlet oxygen as the reactive species. Activation of the metal reagent via photoaquation with low energy light will localize the activated complex in the irradiated area. The role that cis-platin plays as an antitumor drug includes severe limitations that justify seeking alternative metal complexes as DNA binders. The possibility of selective photoactivation of ruthenium complexes that will bind to DNA drives this research project. Broad based training in coordination chemistry, biochemistry and photochemistry offer multiple advantages to students while developing important fundamental photophysical principles.

Claudia Turro教授是俄亥俄州州立大学化学系的一名教员，他与来自德克萨斯州农工大学的Kim Dunbar教授一起担任共同研究员，他们得到了无机、生物无机和有机化学项目的支持，设计出可以被光活化并与DNA结合的金属络合物。将开发新的钌络合物以提供产生单线态氧作为活性物质的光动力治疗剂的替代物。 通过用低能量光的光致水合作用活化金属试剂将使活化的络合物定位在照射区域中。顺铂作为抗肿瘤药物的作用包括严重的局限性，这证明寻求替代金属络合物作为DNA结合剂是合理的。选择性光活化钌络合物的可能性，将结合到DNA驱动这个研究项目。 在配位化学，生物化学和光化学方面的广泛培训为学生提供了多种优势，同时发展了重要的基本生物物理原理。