Design, Synthesis, and Photochemistry of New Ru(II) Complexes as Potential Photo-Cisplatin Analogs

作为潜在光顺铂类似物的新型 Ru(II) 配合物的设计、合成和光化学

• 批准号: 0911354
• 负责人: Claudia Turro
• 金额: $ 69万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911354&HistoricalAwards=false
• 关键词: Design; Synthesis; Photochemistry; New; Ru

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Claudia Turro at The Ohio State University to carry out fundamental/basic studies on ligand-loss photochemistry of ruthenium complexes. The aim of the research is to design new metal complexes that can undergo ligand exchange with water molecules with low energy visible light, such that, when photoactivated, these systems will bind to DNA. The main goal of the research is to understand the principles that govern efficient excited state ligand-loss, its kinetics, and how this excited state process can be enhanced. Understanding how the binding properties of the leaving ligand and the structural characteristics of the ground state and the lowest energy excited state affect the photochemistry represents a primary focus of the work. Other ligands around the metal centered will be systematically varied in order to induce ligand exchange using low energy light. Once activated with light, the ruthenium complexes bind to DNA in an oxygen-independent manner. This work will provide the basic knowledge that can later be applied to the discovery of new antitumor agents that may circumvent the drawbacks of current drugs.The PI and both co-PIs are committed to the education of graduate and undergraduate students, as well as members of underrepresented groups. The PI is the faculty advisor for the student chapter of the National Organization of Black Chemists and Chem. Engineers at OSU, is a member of the departmental Diversity Committee, and attended national and regional meetings of societies geared to promote and retain underrepresented minorities and women in science. These efforts will aid in the training of highly qualified, diverse scientists at the undergraduate and graduate levels. An important aspect of the research is the potential for the new complexes derived from this work to act as antitumor agents, thus providing a clear benefit to society.

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。这一无机化学、生物无机化学和金属有机化学项目的研究奖支持俄亥俄州立大学的Claudia Turro教授开展有关Ru络合物的配体丢失光化学的基础/基础研究。这项研究的目的是设计新的金属络合物，可以与低能量可见光下的水分子进行配体交换，这样当被光激活时，这些系统将与DNA结合。这项研究的主要目的是了解控制有效的激发态配体损失的原理，它的动力学，以及如何增强这个激发态过程。了解离开配体的结合性质以及基态和最低能量激发态的结构特征如何影响光化学是这项工作的主要重点。金属中心周围的其他配体将被系统地改变，以便利用低能量光诱导配体交换。一旦用光激活，Ru络合物就以不依赖于氧的方式与DNA结合。这项工作将提供基础知识，以后可以应用于发现新的抗肿瘤药物，以绕过现有药物的缺点。PI和两个共同PI致力于研究生和本科生以及代表性不足群体的成员的教育。PI是全国黑人化学家和化学组织学生分会的教员顾问。OSU的工程师，是部门多样性委员会的成员，并出席旨在促进和留住科学界代表性不足的少数群体和妇女的学会的国家和区域会议。这些努力将有助于培养高素质、多样化的本科生和研究生科学家。这项研究的一个重要方面是从这项工作中衍生的新络合物作为抗肿瘤药物的潜力，从而为社会提供明显的好处。