US Egypt Cooperative Research: Design, Fabrication and Characterization of Titanium Implants

0506116 Soboyejo描述：该项目支持普林斯顿大学机械和航空航天工程系的Winston Soboyejo博士和埃及亚历山大牙科学院的莫纳马雷博士之间的合作研究。 他们计划对钛种植体的制造和表征进行研究。智力优势：最近的研究表明，在种植体和骨整合的许多途径，以改善牙科螺钉设计，这项研究将调查的制造，设计和表征的新型螺钉表面，并量化对骨整合的影响。 将RGD肽化学键合至Laser-LokTM（BioLok International Inc.）通过一种新的自组装技术，制造了含有激光槽（8和12微米宽）的牙科螺钉。这种努力将联合收割机的积极影响，激光开槽和RGD功能化的表面都分别显示对细胞粘附和附着。 同时，将设计螺钉以容纳PLGA聚合物支架，从而允许在聚合物支架和钛螺钉的界面处进行机械固定。通过铸造，CNC切割和表面处理完成的方法成功制造将以所需形状生产高度精确的植入物。设计的螺钉和表面将在动物模型中进行测试，并对其材料性能进行分析，以及SEM成像和IR分析。将检查所有样本，以通过X光片图像、用于BMD计算的双能X线吸收测定法（DEXA）、组织形态测定法和显微硬度/纳米硬度测试来量化骨整合水平。对微化学的进一步分析将包括扫描电镜成像和能谱分析，以揭示钙的浓度。 它还涉及在普林斯顿大学培训一名本科生。该项目将在生物和材料表面改性领域开展合作。 通过该计划，将实现对钛植入物的正确理解。学生知识的交流是该提案的优势之一。研究结果将纳入PI的教学和教育活动。该项目得到了美国-埃及联合基金方案的支持，该方案向两国的科学家和工程师提供赠款，以开展这些合作活动。

0506116SoboyejoDescription: This project supports a collaborative research between Dr. Winston Soboyejo, Department of Mechanical and Aerospace Engineering, Princeton University and Dr. Mona Marei, College of Dentistry, Alexandria, Egypt. They plan to conduct studies on the fabrication and characterization of titanium implants.Intellectual Merit: Recent research in implants and osseointegration suggests many avenues for improvement in dental screw design; this study will investigate the fabrication, design, and characterization of novel screw surfaces, and quantify the effects on osseointegration. The RGD peptide will be chemically bonded to Laser-LokTM (BioLok International Inc.) dental screws containing laser-grooves (8 and 12 micrmeter width) via a novel self-assembly technique. This effort will combine the positive effects that the laser-grooved and the RGD-functionalized surfaces have both shown individually toward cellular adhesion and attachment. In parallel, a screw will be designed to accommodate a PLGA polymer scaffold permitting mechanical fixation at the interface of the polymer scaffold and titanium screw. Successful fabrication through methods of casting, CNC cutting, and finalizing with surface treatments will produce a highly precise implant in the desired shape. The designed screws and surfaces will be tested in an animal model, and its material properties analyzed, as well as SEM imaging and IR analysis. All samples will be examined to quantify the level of osseointegration via radiograph images, dual energy X-ray absorptiometry (DEXA) for BMD calculations, histomorphometry, and microhardness/nanohardness testing. Additional analysis of the microchemistry will include SEM imaging and EDS to reveal calcium concentrations.Broader impacts: The project involves development of materials that are of important application in the health field. It also involves training of an undergraduate student at Princeton University. The project will develop collaboration in the field of bio and surface modification of materials. Proper understanding of the titanium implants will be achieved through this program. Exchange of student knowledge is one of the strength in the proposal. The research results will be integrated into the PI's teaching and educational activities. This project is being supported under the US-Egypt Joint Fund Program, which provides grants to scientists and engineers in both countries to carry out these cooperative activities.