Investigation of bone defects and microcirculation with volume computed tomography and dy-namic contrast-enhanced magnetic resonance imaging ((13) B08)

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Clinical studies: Continuation of the cohort study initiated in the second period and inclusion of additional patients with smoldering multiple myeloma for the detection of bone marrow lesions before occurrence of frank bone destructions. High-resolution and functional MRI as well as positron emission tomography for new-detected bone marrow lesions and imaging-guided biopsy of non-osteolytic lesions. Preclinical studies: In vivo analysis of perfusion, diffusion and fine bone structure (SP T1, T2 and B1) using ultra-HF-small animal MRI and micro-CT as well as PET by using standard and BCMA tracers (SP B13) employing a rat and mouse model.