A self-driven intramedullary nail for the reconstruction of large bone defects
用于重建大骨缺损的自驱动髓内钉
基本信息
- 批准号:MR/Z503836/1
- 负责人:
- 金额:$ 31.2万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2024
- 资助国家:英国
- 起止时间:2024 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
This project aims to evaluate a self-driven bone transport nail developed to reconstruct large bone defects caused by trauma, deformity, or cancer. Bone transport is an intervention whereby new bone is grown in a long bone where there is a missing section. It requires the division of the intact portion of the bone leaving a segment of bone that can be transported from its location in a controlled manner using either an intramedullary nail or an external ring fixation. External fixation is the preferred technique in the UK due to lower cost and lack of availability of other options that has a number of significant limitations, which are: prolonged treatment time, diligent care, as well as psychological, hygiene, and daily activity burden for patients and caregivers. Intramedullary bone transport methods also have a number of limitations that include: the daily involvement of patients during the distraction process; regular interventions by surgeons; and the significant cost of the procedure. These limitations have led to limited use of this method regardless of its superior outcomes compared to the external fixator method.Addressing these limitations is the subject of this project: automating the process and significantly reducing its cost can considerably promote the use of nails in the UK as the primary technique for bone transport. In this project, we will experimentally demonstrate the feasibility and accuracy of the nail using an in vivo study on sheep. We will also engage with patient groups at the Royal National Orthopaedic Hospital during the study. This is to ensure it is well accepted and can be rapidly included in the current treatment pathway within the NHS once the clinical trials have been completed.
本项目旨在评价一种自驱动骨运输髓内钉,用于重建由创伤、畸形或癌症引起的大面积骨缺损。骨转移是一种干预,通过这种干预,新骨在缺失部分的长骨中生长。它需要分割骨的完整部分,留下一段骨,可以使用髓内钉或外环固定以受控的方式从其位置转移。外固定是英国的首选技术,原因是成本较低且缺乏其他选择,这些选择具有许多显著的局限性,包括:治疗时间延长、护理细致以及患者和护理人员的心理、卫生和日常活动负担。髓内骨运输方法也有许多局限性,包括:在牵引过程中患者的日常参与;外科医生的定期干预;以及手术的巨大成本。这些局限性导致这种方法的使用受到限制,尽管与外固定器方法相比,它具有上级效果,但解决这些局限性是本项目的主题:自动化过程和显著降低其成本可以大大促进在英国使用髓内钉作为骨运输的主要技术。在本项目中,我们将通过对绵羊的体内研究,通过实验证明髓内钉的可行性和准确性。在研究期间,我们还将与皇家国家骨科医院的患者团体进行接触。这是为了确保它被很好地接受,并且一旦临床试验完成,就可以迅速纳入NHS内的当前治疗途径。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Anthony Bull其他文献
370 - Osteoarthritis After Major Combat Trauma: The ADVANCE Study
- DOI:
10.1016/j.joca.2024.02.382 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:
- 作者:
Fearghal Behan;Alex Bennett;Susie Schofield;Eleanor Miller;Anthony Bull - 通讯作者:
Anthony Bull
072 - PREVALENCE, AND 3-YEAR PROGRESSION AND INCIDENCE OF RADIOGRAPHIC HIP OSTEOARTHRITIS IN A YOUNG MILITARY POPULATION POST MAJOR TRAUMA: THE ADVANCE STUDY
072 - 主要创伤后年轻军事人群中放射学髋关节骨关节炎的患病率、3 年进展和发生率:前瞻性研究
- DOI:
10.1016/j.joca.2025.02.076 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:9.000
- 作者:
Fraje Watson;Rintje Agricola;Alex Bennett;Anthony Bull - 通讯作者:
Anthony Bull
369 - Radiographic Knee Osteoarthritis Differs Between Races: The ADVANCE Study
- DOI:
10.1016/j.joca.2024.02.381 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:
- 作者:
Fearghal Behan;Susie Schofield;Fraje Watson;Alex Bennett;Anthony Bull - 通讯作者:
Anthony Bull
Can Subscapularis Deficiency Explain Glenoid Wear (Thus Possibly Glenohumeral Pain)
- DOI:
10.1016/j.jseint.2024.08.151 - 发表时间:
2024-11-01 - 期刊:
- 影响因子:
- 作者:
Ulrich Hansen;Hazimah Mahmud;Andra Topan;Anthony Bull;Roger Emery;Sanjeeve Sabharwal;Peter Reilly - 通讯作者:
Peter Reilly
373 - LONGITUDINAL INCIDENCE AND PROGRESSION RATES AND PREDICTION OF KNEE RADIOLOGICAL OSTEOARTHRITIS AND PAIN IN THE ADVANCE COHORT
373 - 纵向发病率、进展率以及对“前进队列”研究中膝关节影像学骨关节炎和疼痛的预测
- DOI:
10.1016/j.joca.2025.02.379 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:9.000
- 作者:
Oliver O'Sullivan;Fraje Watson;Anthony Bull;Susie Schofield;Stefan Kluzek;Alex Bennett;Ana Valdes - 通讯作者:
Ana Valdes
Anthony Bull的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Anthony Bull', 18)}}的其他基金
Low cost through knee prostheses. TaKeuP
通过膝关节假体实现低成本。
- 批准号:
EP/R014248/1 - 财政年份:2018
- 资助金额:
$ 31.2万 - 项目类别:
Research Grant
相似国自然基金
Data-driven Recommendation System Construction of an Online Medical Platform Based on the Fusion of Information
- 批准号:
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国青年学者研究基金项目
基于Cache的远程计时攻击研究
- 批准号:60772082
- 批准年份:2007
- 资助金额:28.0 万元
- 项目类别:面上项目
相似海外基金
Priceworx Ultimate+: A world-first AI-driven material cost forecaster for construction project management.
Priceworx Ultimate:世界上第一个用于建筑项目管理的人工智能驱动的材料成本预测器。
- 批准号:
10099966 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
Collaborative R&D
Facilitating circular construction practices in the UK: A data driven online marketplace for waste building materials
促进英国的循环建筑实践:数据驱动的废弃建筑材料在线市场
- 批准号:
10113920 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
SME Support
N2Vision+: A robot-enabled, data-driven machine vision tool for nitrogen diagnosis of arable soils
N2Vision:一种由机器人驱动、数据驱动的机器视觉工具,用于耕地土壤的氮诊断
- 批准号:
10091423 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
Collaborative R&D
Structure-guided optimisation of light-driven microalgae cell factories
光驱动微藻细胞工厂的结构引导优化
- 批准号:
DP240101727 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
Discovery Projects
Data Driven Discovery of New Catalysts for Asymmetric Synthesis
数据驱动的不对称合成新催化剂的发现
- 批准号:
DP240100102 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
Discovery Projects
Maintaining Human Expertise in an AI-driven World
在人工智能驱动的世界中保持人类的专业知识
- 批准号:
DE240100269 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
Discovery Early Career Researcher Award
PIDD-MSK: Physics-Informed Data-Driven Musculoskeletal Modelling
PIDD-MSK:物理信息数据驱动的肌肉骨骼建模
- 批准号:
EP/Y027930/1 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
Fellowship
EDIBLES: Environmentally Driven Body-Scale Electromagnetic Co-Sensing
食用:环境驱动的人体规模电磁协同感应
- 批准号:
EP/Y002008/1 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
Research Grant
Understanding the Impact of Outdoor Science and Environmental Learning Experiences Through Community-Driven Outcomes
通过社区驱动的成果了解户外科学和环境学习体验的影响
- 批准号:
2314075 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
Continuing Grant
CAREER: CAS: Organic Photochemistry for Light-Driven CO2 Capture and Release
职业:CAS:光驱动二氧化碳捕获和释放的有机光化学
- 批准号:
2338206 - 财政年份:2024
- 资助金额:
$ 31.2万 - 项目类别:
Continuing Grant