DISSERTATION RESEARCH: Molecular Phylogeny of Verrucariales (Fungi, Ascomycota) and the Evolution of Nutritional Modes.

论文研究：疣状菌目（真菌、子囊菌）的分子系统学和营养模式的演变。

• 批准号: 0508567
• 负责人: Francois Lutzoni
• 金额: $ 1.07万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0508567&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Molecular; Phylogeny; Verrucariales

The Verrucariales is a poorly studied group of mostly rock-dwelling lichens (fungi in mutualistic association with algae). They are found in varied habitats ranging from marine and fresh water to dry environments. The discovery that some human pathogens are derived from lichen-forming ancestor was unexpected and needs to be further investigated. First, DNA sequences will be obtained for a large sampling of Verrucariales and the classification of this order will be revised. Second, the sampling will be expanded to the Chaetothyriales and the transition from mutualistic lichen ancestors to animal and human pathogens will be characterized using computational methods. Because of their diversity in lifestyles, these two orders are ideal to study the changes of nutritional modes in fungi. This project will be the first extensive molecular study on the Verrucariales and will greatly contribute to the understanding of this poorly known order of fungi. It will have a broader impact in developing new protocols suitable for microbes that are not amenable to molecular studies. Finally, it will enhance our understanding of the origin of fungal pathogenicity.

疣孢目是一个研究很少的群体，主要是岩石地衣（真菌与藻类互利共生）。它们存在于从海洋和淡水到干燥环境的各种生境中。一些人类病原体起源于地衣形成祖先的发现是出乎意料的，需要进一步研究。首先，将获得一个大样本的疣孢目的DNA序列，并将修订该目的分类。第二，采样将扩大到毛藻目和互利地衣祖先的动物和人类病原体的过渡将使用计算方法的特点。由于生活方式的多样性，这两个目的是理想的研究营养模式的变化在真菌。该项目将是对疣孢目的第一次广泛的分子研究，并将大大有助于了解这种鲜为人知的真菌。它将在开发适用于不适合分子研究的微生物的新方案方面产生更广泛的影响。最后，它将加强我们对真菌致病性起源的理解。