Cyclic Loading Induced Fluid Flow Associated with Mechanotransduction in Bones

骨内流体流动的模拟在生物力学领域受到了广泛的关注。有限的研究已经进行到目前为止，以调查变形和流体压力的骨在良好的控制条件。提出了一系列的实验研究，以探讨骨试件在单调后循环加载下的响应。在实验中，骨标本被限制在橡胶膜中，使用一个新开发的装置封闭的全方位压力。分别测量了排水和不排水条件下的诱导变形和流体压力。揭示了不同应力幅值和频率下循环加载下塑性应变和流体累积压力的发展规律。该研究是应用力学（地质力学）和医学科学之间的跨学科和跨机构研究。对载荷诱导的流体流动机制的理解将有助于更好地解释骨骼的机械感觉功能，这具有重要的临床意义。

The simulation of fluid flow in bones has received considerable attention in the field of biomechanics. Limited studies have been conducted up to date to investigate the deformation and fluid pressure of bone under well controlled conditions. A series of experimental studies is proposed to investigate the response of bone specimens under monotonic followed by cyclic loadings. In the experiment, the bone specimen is confined in a rubber membrane using an all-around pressure enclosed in a newly developed device. The induced deformation and fluid pressure are measured under drained and undrained conditions, respectively. The development of plastic strains and accumulated fluid pressure under cyclic loading will be revealed for different stress amplitudes and frequencies. The study is undertaken as a cross-disciplinary and cross-institutional research between applied mechanics (geomechanics) and medical science. The understanding of mechanisms of load-induced fluid flow would lead to a better interpretation of mechanosensory function in bones that has significant clinical implications.