Cyclic Loading Induced Fluid Flow Associated with Mechanotransduction in Bones

循环加载引起的流体流动与骨骼中的机械传导相关

• 批准号: 0510490
• 负责人: Hoe Ling
• 金额: $ 5万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0510490&HistoricalAwards=false
• 关键词: Cyclic; Loading; Induced; Fluid; Flow

The simulation of fluid flow in bones has received considerable attention in the field of biomechanics. Limited studies have been conducted up to date to investigate the deformation and fluid pressure of bone under well controlled conditions. A series of experimental studies is proposed to investigate the response of bone specimens under monotonic followed by cyclic loadings. In the experiment, the bone specimen is confined in a rubber membrane using an all-around pressure enclosed in a newly developed device. The induced deformation and fluid pressure are measured under drained and undrained conditions, respectively. The development of plastic strains and accumulated fluid pressure under cyclic loading will be revealed for different stress amplitudes and frequencies. The study is undertaken as a cross-disciplinary and cross-institutional research between applied mechanics (geomechanics) and medical science. The understanding of mechanisms of load-induced fluid flow would lead to a better interpretation of mechanosensory function in bones that has significant clinical implications.

骨内流体流动的模拟在生物力学领域受到了广泛的关注。到目前为止，已经进行了有限的研究，以调查在良好控制的条件下骨的变形和流体压力。本文通过一系列的实验研究，探讨了骨试件在单调载荷和循环载荷作用下的响应。在实验中，骨标本被限制在一个橡胶膜使用一个新开发的装置封闭的全面压力。分别在排水和不排水条件下测量了诱导变形和流体压力。在不同的应力幅值和频率下，循环载荷下的塑性应变和累积流体压力的发展将被揭示。该研究是应用力学（地质力学）和医学科学之间的跨学科和跨机构的研究。对负荷引起的流体流动机制的理解将导致对骨骼中具有重要临床意义的机械感觉功能的更好解释。