SBIR Phase I: Analytical Control for Micro-Reactor

SBIR 第一阶段：微反应器的分析控制

• 批准号: 0512701
• 负责人: Stuart Farquharson
• 金额: --
• 依托单位: REAL-TIME ANALYZERS, INCORPORATED
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0512701&HistoricalAwards=false
• 关键词: SBIR; Phase; Analytical; Control; Micro

This Small Business Innovation Research (SBIR) Phase I research project will develop Raman spectroscopy as a novel analytical tool to monitor and control chemistry in small-scale reactors (microliter to milliliter). Small scale reactors are being developed to: (1) create new chemical reaction processes; (2) increase yields of existing processes; and, (3) replace scaling-up by numbering-up production. Rapid optimization and successful process operation of these reactors requires analytical measurements to identify and quantify (+/-1%) all reactants and products in real-time (e.g. 1 min), preferably without requiring sample preparation. This Phase I project will demonstrate feasibility by measuring reactants and products during the esterification of benzoic acid. Protecting carboxylic acid groups by esterification is an often-used reaction during the synthesis of pharmaceuticals. Raman spectroscopy will be first used to monitor this reaction in a small-scale reactor under a variety of conditions and then use the real-time data to control yieldIf successful the development of the proposed analytical tool will aid the development and use of small-scale reactors. The proposed analytical tool will be marketed to the Chemical Manufacturing Industry, where it will aid the development of new drugs for clinical trials (pharmaceutical companies), the development of synthetics used in fuels and lubricants (petrochemical companies), and the development of stronger-lighter composites (chemical and manufacturing companies).

这个小型企业创新研究(SBIR)第一阶段研究项目将开发拉曼光谱作为一种新的分析工具，用于监测和控制小型反应堆(从微升到毫升)的化学成分。正在开发小型反应堆以：(1)创造新的化学反应工艺；(2)提高现有工艺的产率；以及(3)通过扩大生产来取代扩大生产。这些反应器的快速优化和成功的工艺操作需要分析测量，以实时(例如1分钟)识别和量化(+/-1%)所有反应物和产物，最好不需要样品准备。这个第一阶段的项目将通过测量苯甲酸酯化过程中的反应物和产物来证明其可行性。在药物合成中，通过酯化保护羧酸基是一种常用的反应。拉曼光谱将首先用来监测小规模反应堆在各种条件下的反应，然后使用实时数据来控制产量。如果成功，所提出的分析工具的开发将有助于小规模反应堆的开发和使用。拟议的分析工具将销售给化学制造行业，在那里它将帮助开发用于临床试验的新药(制药公司)，开发用于燃料和润滑剂的合成化合物(石油化工公司)，以及开发更强、更轻的复合材料(化学和制造公司)。