SBIR Phase I: Novel Fluorous Solvent Systems for Biphasic Catalysis

SBIR 第一阶段：用于双相催化的新型氟溶剂系统

• 批准号: 0512728
• 负责人: Marvin Yu
• 金额: --
• 依托单位: Fluorous Technologies, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0512728&HistoricalAwards=false
• 关键词: SBIR; Phase; Novel; Fluorous; Solvent

This Small Business Innovation Research (SBIR) Phase I project constitutes initial instigations into the use of alternative fluorous solvent systems for biphasic catalysis. Based on preliminary results which demonstrate the enormous impact that solvent tuning can have on fluorous separations, a research plan using alternative fluorous solvent systems in biphasic catalysis is proposed. The objectives of the Phase I research are: (1) To identify alternative fluorous/organic solvent systems suitable for liquidliquid extraction processes. (2) To identify solvent pairings in three reaction modes. (3) To study the features of the three prototype processes.The innovation meets pressing needs of pharmaceutical and chemical manufacturers to produce important small organic molecules on large scale, cost effectively and in a safe and environmentally friendly manner. These alternative solvents are not only more effective, but also less expensive and greener. Fluorous techniques are already being used in a range of applications including drug discovery, small molecule library synthesis, peptide and oligo synthesis, and proteomics. The research proposed will lead to even wider acceptance and use in all areas where separations are problematic.

这个小型企业创新研究（SBIR）第一阶段项目构成了使用替代氟溶剂系统进行双相催化的初步研究。基于溶剂调节对氟分离的巨大影响的初步结果，提出了在双相催化中使用替代氟溶剂体系的研究计划。第一阶段研究的目标是：(1)确定适合液液萃取工艺的替代氟/有机溶剂体系。(2)确定三种反应模式下的溶剂对。(3)研究三种原型工艺的特点。这项创新满足了制药和化工制造商大规模、经济高效、安全环保地生产重要有机小分子的迫切需求。这些替代溶剂不仅更有效，而且更便宜、更环保。含氟技术已经被广泛应用于药物发现、小分子文库合成、肽和寡核苷酸合成以及蛋白质组学等领域。提出的研究将导致更广泛的接受和使用在所有领域的分离是有问题的。