Stimulation of bone defect and fracture healing in systemically impaired bone by biomaterials and metallic implants ((19) T02)

通过生物材料和金属植入物刺激系统性受损骨骼的骨缺损和骨折愈合（（19）T02）

• 批准号: 171510934
• 金额: --
• 依托单位: Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie - Operative Notaufnahme
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/171510934?language=en
• 关键词: Stimulation; bone; defect; fracture; healing

In the third funding period, T2 intends to provide sufficient data for the use of biomaterials to stimulate fracture healing in osteoporotic fracture defects and for biomaterials for the local antiproliferative treatment against multiple myeloma cells for their clinical application in the future by an extension of the observation period from 6 to 16 weeks in a rat model. The second goal is the in vivo evaluation in animal models to analyse the respective material developments of TFP1 and TFP2 after previously conducted in vitro experiments according to the „pyramid principle“ in close cooperation with with two transfer projects.

在第三期资助期内，T2拟通过将大鼠模型观察期从6周延长至16周，为生物材料在骨质疏松性骨折缺陷中促进骨折愈合和局部抗增殖治疗多发性骨髓瘤细胞的生物材料在未来的临床应用提供足够的数据。第二个目标是在动物模型中进行体内评估，根据“金字塔原理”，与两个转移项目密切合作，分析先前在体外实验后TFP1和TFP2各自的材料发展情况。