Carbinolamides and N-(Hydroxybenzyl)urea Derivatives: Structure/Reactivity Correlations and Catalysis of the Aqueous Reaction

甲醇酰胺和 N-(羟基苄基)脲衍生物：结构/反应性相关性和水相反应的催化

• 批准号: 0518130
• 负责人: Richard Nagorski
• 金额: --
• 依托单位: Board of Trustees of Illinois State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0518130&HistoricalAwards=false
• 关键词: Carbinolamides; Hydroxybenzyl; urea; Derivatives; Structure

With this new RUI award, the Organic and Macromolecular Chemistry Program supports the work of Professor Richard Nagorski of the Department of Chemistry at Illinois State University in Normal, Illinois. The research project involves investigations of structure/reactivity correlations and catalysis in the aqueous reactions of carbinolamides and N-(hydroxyalkyl)urea derivatives. Carbinolamides are intermediates in the enzyme catalyzed formation of peptide hormones and N-(hydroxyalkyl)ureas are involved in the production of urea from purines. Despite the biological importance of these compounds, the reactivity and mechanisms by which they react are poorly understood. In order to achieve a better understanding of the chemistry of these species, the rates and products of their aqueous reactions as a function of pH and structure will be investigated. Since very little data exists concerning the reactivity of these compounds, the results will be unique and of broad interest to the biochemical community.These studies, which will increase our knowledge of the underlying reaction mechanisms of molecules and molecular systems that are a part of important biological processes, will have significant impact on the fields of biology, medicinal chemistry, biochemistry and pharmacology. Of equal importance are the benefits to the undergraduate and graduate students who will carry out this research. For many, these studies will represent their first steps into performing scientific investigations that involve techniques and methods that are accessible, yet challenging, to both undergraduate and graduate students. Opportunities of this kind will lead to a scientific community that is better trained and with a wider range of experience.

有了这个新的RUI奖，有机和高分子化学计划支持教授理查德Nagorski的化学系在伊利诺伊州州立大学在正常，伊利诺伊州的工作。 该研究项目涉及甲醇酰胺和N-（羟烷基）脲衍生物在水相反应中的结构/反应性相关性和催化作用的研究。 甲醇酰胺是酶催化形成肽激素的中间体，而N-（羟烷基）脲参与由嘌呤产生尿素。尽管这些化合物具有生物学重要性，但它们的反应性和反应机制却知之甚少。 为了更好地了解这些物种的化学性质，将研究它们的水反应速率和产物随pH值和结构的变化。由于有关这些化合物的反应性的数据很少，因此这些研究结果将是独特的，并引起生物化学界的广泛兴趣。这些研究将增加我们对分子和分子系统的潜在反应机制的认识，这些反应机制是重要生物过程的一部分，将对生物学、药物化学、生物化学和药理学领域产生重大影响。 同样重要的是，将进行这项研究的本科生和研究生的利益。 对许多人来说，这些研究将代表他们进行科学调查的第一步，这些调查涉及的技术和方法对本科生和研究生来说都是可访问的，但具有挑战性。这类机会将导致科学界得到更好的培训和更广泛的经验。