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Cortical and basal ganglia contributions to the acquisition of sequential behavior: A neurostimulation, modeling, magneto- and electroencephalographic approach.

皮质和基底神经节对顺序行为的获得的贡献：神经刺激、建模、脑磁和脑电图方法。

基本信息

批准号：
172576217
负责人：
Professor Dr. Gabriel Curio, since 9/2015
金额：
--
依托单位：
Department of Psychology
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2010
资助国家：
德国
起止时间：
2009-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/172576217?language=en
关键词：
Cortical basal ganglia contributions acquisition

项目摘要

An adequate performance requires the ability to monitor ongoing behavior, detect errors and modify the performance in response to changing environmental conditions. In the context of actionmonitoring, a seminal finding for the neuroscientific community was a negative event-related brain potential, termed error-related negativity (ERN), which peaks 80 ms after a wrong response and is localized in the anterior cingulate cortex. The ERN has been proposed to reflect conflict monitoring or error detection. The reinforcement learning theory has provided an account of the ERN based on phasic dopaminergic activity induced by the basal ganglia (BG). However, despite previous studies showing altered error processing in BG disorders, only few investigations have demonstrated a direct role of the BG (Ncl Accumbens) in the generation of the ERN. Accordingly, we plan to record local field potential activity from the human BG—the STN and the internal globus pallidus (GPi)—in patients undergoing deep brain stimulation during performance of a reaction-time conflict task and an overlearned motor task. Our aims are to investigate the role of these BG structures in conflict processing and feedforward error detection. Our investigations will shed new light on the mechanisms of performance monitoring and motor control. Moreover, a deeper knowledge of BG functioning during action-monitoring will contribute to our understanding of the neural disorders of movement as well.

一个适当的性能需要有能力监测正在进行的行为，检测错误和修改性能，以响应不断变化的环境条件。在动作监测的背景下，神经科学界的一个开创性发现是一个负的事件相关脑电位，称为错误相关负波（ERN），它在错误反应后80 ms达到峰值，并位于前扣带皮层。ERN已经被提出来反映冲突监视或错误检测。强化学习理论基于基底神经节（BG）诱导的阶段性多巴胺能活动提供了ERN的解释。然而，尽管先前的研究显示BG疾病中的错误处理改变，但只有少数研究表明BG（Ncl Accumbens）在ERN的产生中的直接作用。因此，我们计划记录当地的场电位活动，从人类BG的大脑皮层和内部苍白球（GPi）的患者接受脑深部电刺激过程中的反应时间冲突任务和过度学习的运动任务的性能。我们的目标是调查这些BG结构中的冲突处理和前馈错误检测的作用。我们的研究将为性能监测和运动控制的机制提供新的线索。此外，更深入地了解BG在动作监测过程中的功能也将有助于我们理解运动的神经障碍。