Enhancing Multidisciplinarity through Molecular Modeling

通过分子建模增强多学科性

• 批准号: 0536152
• 负责人: Pamela Hanson
• 金额: $ 7.57万
• 依托单位: Birmingham Southern College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0536152&HistoricalAwards=false
• 关键词: Enhancing; Multidisciplinarity; through; Molecular; Modeling

Biological Sciences (61)Intellectual Merit: Two major curricular goals are being achieved through this project. The first is the integration of molecular modeling into all levels of the biology and chemistry curricula at Birmingham-Southern College and the second is the linkage of biology and chemistry courses by making use of a common molecular thread that runs through introductory and upper-level coursework. Students use molecular modeling techniques to study a selected small, bioactive molecule in a variety of contexts. When possible, wet labs are paired with in silico (computer-based) experiments to test hypotheses students develop using a computational approach. Three biology courses, two chemistry courses, and an interdisciplinary biochemistry course are being revised. The inquiry-based pedagogy introduced is cultivating the students' critical thinking skills while at the same time, since they are applying chemical principles to experiments exploring biological phenomena, introducing them to the interdisciplinary nature of modern research and better preparing them for graduate and professional school. In addition, the infrastructure and training provided by these revisions are enabling students to collaborate with faculty on projects exploring polymer folding, cholinesterase evolution, and drug design.Broader Impacts: All educational materials developed as part of this grant will be disseminated to a broad audience through presentations at regional and national meetings, peer-reviewed publications in appropriate journals, and development of a web-site to make the teaching modules freely available for other institutions to use.

生物科学（61）智力优势：通过本项目实现了两个主要课程目标。首先是将分子建模整合到伯明翰南方学院所有层次的生物和化学课程中，其次是通过使用贯穿入门和高级课程的共同分子线索，将生物和化学课程联系起来。学生使用分子建模技术在各种情况下研究选定的小生物活性分子。在可能的情况下，湿实验室与计算机实验配对，以测试学生使用计算方法提出的假设。三门生物课程、两门化学课程和一门跨学科生物化学课程正在修订中。探究性教学法的引入是为了培养学生的批判性思维能力，同时，因为他们将化学原理应用于探索生物现象的实验，向他们介绍现代研究的跨学科性质，为他们研究生和专业学校做更好的准备。此外，这些修订提供的基础设施和培训使学生能够与教师合作开展探索聚合物折叠、胆碱酯酶进化和药物设计的项目。更广泛的影响：作为这笔赠款的一部分编写的所有教育材料将通过在区域和国家会议上的演讲、在适当的期刊上发表同行评议的出版物，以及开发一个网站，使教学模块免费供其他机构使用，向广泛的受众传播。