CAREER: Supramolecular Main Group Coordination Chemistry

这项由无机化学、生物无机化学和金属有机化学项目颁发的职业奖项支持俄勒冈大学的Darren Johnson教授的工作，该项目将主要基团超分子配位化学的基础研究与区域公司和国家实验室的环境化学研究生的实习机会联系起来。这项研究致力于开发一种预测设计策略，以形成自组装的纳米级主族超分子络合物。通过利用As3和Pb2的不寻常的配位几何结构来开发形成超分子络合物的设计策略，产生了新的超分子结构类型，提供了能够表现出不寻常的主客体化学的三维分子。将这些有毒金属的配位偏好编程到设计策略中，将提供不仅针对目标金属离子的新配体，而且还可以形成极其稳定的络合物。从事这一项目的学生将有机会将他们所学到的配基设计知识应用于开发用于补救和传感的材料，方法是在区域公司和国家实验室进行校外实习。其他教育活动包括在俄勒冈大学(UO)的本科有机课程中增加同行主导的团队学习部分，增加聚合物合成和表征的沉浸式实验室，以提高我们硕士级聚合物课程中解决问题和团队合作的技能，以及支持新成立的女性研究生科学小组举办研讨会和研讨会系列，为小组成员创造新的网络和职业发展机会。这项研究旨在推进砷和铅配位化学的基础科学，这将导致在环境和体内有毒金属修复、传感和配体设计领域的长期应用。教育活动将1)为学生提供实习机会，以便在地区行业或国家实验室研究其研究的更多应用方面；2)在密歇根大学的本科生有机化学和硕士级别的聚合物化学课程中增加新的课程，以提高解决问题和团队合作的技能；3)为密歇根大学新成立的女性研究生科学小组成员举办研讨会和系列讲习班提供支持。

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Darren Johnson at the University of Oregon to develop a program that links fundamental research in main group supramolecular coordination chemistry to internship opportunities for graduate students in environmental chemistry at regional companies and national laboratories. The research focuses on developing a predictive design strategy for forming self-assembled nanoscale main group supramolecular complexes. By using the unusual coordination geometries of As3+ and Pb2+ to develop a design strategy for forming supramolecular complexes, new supramolecular structure types result, providing three-dimensional molecules that are capable of exhibiting unusual host-guest chemistry. Programming the coordination preferences of these toxic metals into the design strategy will provide new ligands that are not only specific for the targeted metal ions, but also form extremely stable complexes. Students working on this project will have the opportunity to apply what they learn about ligand design to developing materials for remediation and sensing by performing off-campus internships at regional companies and national laboratories. Other educational activities include adding a Peer-Led Team Learning component to the undergraduate organic curriculum at the University of Oregon (UO), adding an immersion lab in polymer synthesis and characterization to improve the problem-solving and team-working skills in our masters-level polymer program, and providing support for the new Women in Graduate Sciences group to run a workshop and seminar series to create new networking and career-development opportunities for the group's members. The research aims to advance the basic science of arsenic and lead coordination chemistry, which will lead to long-term applications in the area of environmental and in vivo toxic metal remediation, sensing and ligand design. The educational activities will 1) provide internship opportunities for students to investigate more applied aspects of their research at regional industry or a national laboratory, 2) add new curricula to undergraduate organic chemistry and masters-level polymer chemistry courses at UO to improve problem-solving and team-working skills, and 3) provide support for a seminar and workshop series for members of the new Women in Graduate Sciences group at UO.