CAREER: Supramolecular Main Group Coordination Chemistry

无机，生物无机和有机化学计划的职业奖支持俄勒冈州大学的Darren约翰逊教授的工作，以开发一个将主群超分子配位化学的基础研究与区域公司和国家实验室环境化学研究生的实习机会联系起来的计划。 本研究的重点是发展一种预测性设计策略，以形成自组装纳米级主基超分子复合物。 通过使用As 3+和Pb 2+的不寻常的配位几何形状来开发用于形成超分子络合物的设计策略，产生新的超分子结构类型，提供能够表现出不寻常的主客体化学的三维分子。 将这些有毒金属的配位偏好编程到设计策略中将提供新的配体，这些配体不仅对目标金属离子具有特异性，而且还能形成极其稳定的配合物。从事该项目的学生将有机会通过在区域公司和国家实验室进行校外实习，将他们所学的配体设计知识应用于开发补救和传感材料。 其他教育活动包括在俄勒冈州大学（UO）的本科有机课程中增加同行领导的团队学习组件，在聚合物合成和表征中增加沉浸式实验室，以提高我们的硕士级聚合物计划中解决问题和团队合作的技能，并为新成立的妇女研究生科学小组提供支持，以举办一系列讲习班和研讨会，创造新的网络和职业-集团成员的发展机会。 该研究旨在推进砷和铅配位化学的基础科学，这将导致在环境和体内有毒金属修复，传感和配体设计领域的长期应用。 教育活动将1）为学生提供实习机会，以调查他们在区域工业或国家实验室研究的更多应用方面，2）在UO的本科有机化学和硕士水平的高分子化学课程中添加新课程，以提高解决问题和团队合作技能，和3）提供支持的研讨会和讲习班系列的新的妇女在研究生科学组的成员在UO。

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Darren Johnson at the University of Oregon to develop a program that links fundamental research in main group supramolecular coordination chemistry to internship opportunities for graduate students in environmental chemistry at regional companies and national laboratories. The research focuses on developing a predictive design strategy for forming self-assembled nanoscale main group supramolecular complexes. By using the unusual coordination geometries of As3+ and Pb2+ to develop a design strategy for forming supramolecular complexes, new supramolecular structure types result, providing three-dimensional molecules that are capable of exhibiting unusual host-guest chemistry. Programming the coordination preferences of these toxic metals into the design strategy will provide new ligands that are not only specific for the targeted metal ions, but also form extremely stable complexes. Students working on this project will have the opportunity to apply what they learn about ligand design to developing materials for remediation and sensing by performing off-campus internships at regional companies and national laboratories. Other educational activities include adding a Peer-Led Team Learning component to the undergraduate organic curriculum at the University of Oregon (UO), adding an immersion lab in polymer synthesis and characterization to improve the problem-solving and team-working skills in our masters-level polymer program, and providing support for the new Women in Graduate Sciences group to run a workshop and seminar series to create new networking and career-development opportunities for the group's members. The research aims to advance the basic science of arsenic and lead coordination chemistry, which will lead to long-term applications in the area of environmental and in vivo toxic metal remediation, sensing and ligand design. The educational activities will 1) provide internship opportunities for students to investigate more applied aspects of their research at regional industry or a national laboratory, 2) add new curricula to undergraduate organic chemistry and masters-level polymer chemistry courses at UO to improve problem-solving and team-working skills, and 3) provide support for a seminar and workshop series for members of the new Women in Graduate Sciences group at UO.