CAREER: Probing Nucleic Acid Structure through Gas-Phase Ion-Electron Reactions

密歇根大学的Kristina Hakansson教授得到化学系分析和表面化学项目的支持，研究新型气相离子-电子反应（电子捕获解离（ECD）和电子分离解离（EDC）），并开发基于这些电离机制的工具，用于核酸（DNA和RNA）的质谱鉴定。 其最终目标是表征核酸的高级结构，并绘制阿昔肽-药物复合物中的结合位点。 密歇根大学将研究活动与多样性项目相结合，鼓励女性和代表性不足的少数民族走上科学事业的道路。这项工作将增加气相电离过程的基础知识，并导致开发用于识别和表征核酸的质谱工具。 它将对基础生物学和生命过程的分子基础、药物发现和法医学等关键领域产生重大影响。

Professor Kristina Hakansson of the University of Michigan is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to study novel gas-phase ion-electron reactions (electron capture dissociation (ECD) and electron detachment dissociation (EDC)), and to develop tools based on these ionization mechanisms for the mass spectrometric identification of nucleic acids (DNA and RNA). The ultimate goal is to characterize the high order structures of nucleic acids and to map the binding sites in oligonucleotide-drug complexes. The integration of the research activities with diversity programs at the University of Michigan encourages women and underrepresented minorities to embark on scientific careers.The work will add to the fundamental knowledge of gas phase ionization processes, and result in the development of mass spectrometric tools for the identification and characterization of nucleic acids. It will significantly impact crucial areas as diverse as basic biology and the molecular basis of life processes, drug discovery, and forensic science.