CAREER: Probing Nucleic Acid Structure through Gas-Phase Ion-Electron Reactions

职业：通过气相离子电子反应探测核酸结构

• 批准号: 0547699
• 负责人: Kristina Hakansson
• 金额: $ 56万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547699&HistoricalAwards=false
• 关键词: CAREER; Probing; Nucleic; Acid; Structure

Professor Kristina Hakansson of the University of Michigan is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to study novel gas-phase ion-electron reactions (electron capture dissociation (ECD) and electron detachment dissociation (EDC)), and to develop tools based on these ionization mechanisms for the mass spectrometric identification of nucleic acids (DNA and RNA). The ultimate goal is to characterize the high order structures of nucleic acids and to map the binding sites in oligonucleotide-drug complexes. The integration of the research activities with diversity programs at the University of Michigan encourages women and underrepresented minorities to embark on scientific careers.The work will add to the fundamental knowledge of gas phase ionization processes, and result in the development of mass spectrometric tools for the identification and characterization of nucleic acids. It will significantly impact crucial areas as diverse as basic biology and the molecular basis of life processes, drug discovery, and forensic science.

密歇根大学的Kristina Hakansson教授得到化学系分析和表面化学项目的支持，研究新型气相离子-电子反应（电子捕获离解（ECD）和电子分离离解（EDC）），并开发基于这些电离机制的工具，用于核酸（DNA和RNA）的质谱鉴定。最终目标是表征核酸的高阶结构，并绘制寡核苷酸-药物复合物的结合位点。密歇根大学将研究活动与多元化项目相结合，鼓励女性和未被充分代表的少数族裔走上科学事业。这项工作将增加气相电离过程的基础知识，并导致用于鉴定和表征核酸的质谱工具的发展。它将显著影响各种关键领域，如基础生物学和生命过程的分子基础、药物发现和法医学。