RUI: Scanning Electrochemical Microscopy Combined with Surface Plasmon Resonance for Studies of Localized Surface Reactions and Fabrication of Multiplexing Sensors

RUI：扫描电化学显微镜与表面等离子共振相结合，用于研究局部表面反应和多路复用传感器的制造

• 批准号: 0555224
• 负责人: Feimeng Zhou
• 金额: --
• 依托单位: California State L A University Auxiliary Services Inc.
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0555224&HistoricalAwards=false
• 关键词: RUI; Scanning; Electrochemical; Microscopy; Combined

The Analytical and Surface Chemistry (ASC) program of the Division of Chemistry will support the research program of Prof. Feimeng Zhou of California State University at Los Angeles, a Research Undergraduate Institution (RUI). Prof. Zhou and his students will combine scanning electrochemical microscopy (SECM) with surface plasmon resonance (SPR) to study redox-induced protein conformational changes in highly localized surface regions. They will utilize the high sensitivity of SPR and take advantage of the high spatial resolution provided by the microelectrode tip of the SECM to measure infinitesimal structural and conformational changes of surface-confined biomolecules. The group will fabricate microarray chips that could be used to analyze biologically important species with a high sample throughput. The study will provide an excellent training opportunity for undergraduate students from underrepresented groups in an interdisciplinary field at the forefront of scientific research towards the development of advanced biosensors and analytical instrumentation.

化学系的分析和表面化学（ASC）计划将支持洛杉矶的加州州立大学的Feimeng Zhou教授的研究计划，这是一个研究型本科院校（RUI）。 周教授和他的学生将联合收割机扫描电化学显微镜（SECM）与表面等离子体共振（SPR）相结合，研究氧化还原诱导的高度局部表面区域的蛋白质构象变化。 它们将利用SPR的高灵敏度，并利用SECM的微电极尖端提供的高空间分辨率来测量表面限制的生物分子的微小结构和构象变化。 该小组将制造微阵列芯片，可用于分析生物学上重要的物种与高样品通量。 该研究将为来自代表性不足的群体的本科生提供一个极好的培训机会，该群体处于科学研究的前沿，致力于开发先进的生物传感器和分析仪器。