RUI: Scanning Electrochemical Microscopy Combined with Surface Plasmon Resonance for Studies of Localized Surface Reactions and Fabrication of Multiplexing Sensors

化学系分析与表面化学（ASC）项目将资助美国加州州立大学洛杉矶分校周飞梦教授的研究项目。周教授和他的学生将结合扫描电化学显微镜（SECM）和表面等离子体共振（SPR）来研究氧化还原诱导的高度局部表面区域的蛋白质构象变化。他们将利用SPR的高灵敏度和SECM微电极尖端提供的高空间分辨率来测量表面受限生物分子的无限小结构和构象变化。该小组将制造微阵列芯片，可用于分析具有高样本吞吐量的生物学重要物种。这项研究将为在科学研究前沿的跨学科领域中来自代表性不足群体的本科生提供一个极好的培训机会，以开发先进的生物传感器和分析仪器。

The Analytical and Surface Chemistry (ASC) program of the Division of Chemistry will support the research program of Prof. Feimeng Zhou of California State University at Los Angeles, a Research Undergraduate Institution (RUI). Prof. Zhou and his students will combine scanning electrochemical microscopy (SECM) with surface plasmon resonance (SPR) to study redox-induced protein conformational changes in highly localized surface regions. They will utilize the high sensitivity of SPR and take advantage of the high spatial resolution provided by the microelectrode tip of the SECM to measure infinitesimal structural and conformational changes of surface-confined biomolecules. The group will fabricate microarray chips that could be used to analyze biologically important species with a high sample throughput. The study will provide an excellent training opportunity for undergraduate students from underrepresented groups in an interdisciplinary field at the forefront of scientific research towards the development of advanced biosensors and analytical instrumentation.