Identification and Modeling of Cells

细胞的识别和建模NSF ECS-0555394 Erwei Bai，爱荷华大学摘要智力成果本研究的目的是开发和测试细胞建模的识别方法。该方法是建立一个数学模型的基础上细胞的生理和电特性，并通过实验验证，从内皮细胞和上皮细胞。复杂细胞系统的辨识与建模不同于任何工程建模问题，是辨识研究者面临的一项非常具有挑战性的任务。必须开发和分析新的识别方法。特别是，由非线性偏微分方程描述的系统的识别方法必须开发。研究结果将为其他非工程系统的识别和建模奠定基础。更广泛的影响研究将对纳米水平的细胞理解和新药开发产生影响。例如，内皮细胞和上皮细胞提供保护屏障以维持组织区室的稳态分离。炎症性疾病，例如，许多肺部疾病依赖于内皮和上皮细胞-细胞和细胞-基质粘附的改变。为了治疗这些疾病，理解这种行为是至关重要的。利用该模型，可以研究不同药物刺激下的细胞-细胞和细胞-基质粘附特性，从而可以测试和开发新药。这项研究将对教育产生影响。这将导致博士学位。硕士论文，并提供有前途的本科生有机会参与最先进的研究。

Identification and modeling of cellsNSF ECS-0555394Erwei Bai, University of IowaAbstractIntellectual MeritThe objective of this research is to develop and test an identification method for cell modeling. The approach is to build a mathematical model based on cells physiological and electrical properties and validated by experiments, starting with endothelial and epithelial cells. Identification and modeling of a complex cell system is unlike any engineering modeling problem and imposes a very challenge task to identification researchers. New identification methods have to be developed and analyzed. Especially, identification methods for systems described by a nonlinear partial differential equation have to be developed. It is expected that the results of the research will lay a foundation for identification and modeling of other non-engineering systems.Broader ImpactsThe research will impact on understanding of cells at the nanometer level and on new drug developments. For example, endothelial and epithelial cells provide protective barriers to maintain homeostatic separation of tissue compartments. Inflammatory disorders, e.g., a number of lung diseases, depend on alterations in endothelial and epithelial cell-cell and cell-matrix adhesion. It is critical to understand such behavior in order to treat these disorders. With the developed model, cell-cell and cell-matrix adhesion properties could be studied under different drug stimuli so new drugs could be tested and developed. The research will have an impact on education. It will lead to Ph.D./MS theses and provide promising undergraduate students an opportunity to be involved in the state of the art research.