Catalytic Addition of Nucleophiles to Unactivated Olefins

本项目致力于开发Pd（II）-、Pt（II）-和Au（I）-催化的工艺，用于将C-、N-和O-亲核试剂加成到未活化的烯烃中。铂催化的吲哚烷基化反应的范围将被探索，并将开发一种有效的联烯基吲哚的不对称环化反应。还将探索Pt催化的烯基胺的氢胺化和烯基氨基甲酸酯的氢胺化方法。预定用于检查的其他反应包括联烯的分子内氢胺化、未活化烯烃的分子间氢胺化、烯基吲哚的Pd催化的环化/烷氧羰基化和羟基烯烃的Pt催化的氢烷氧基化。与北卡罗来纳州中央大学（NCCU）的夏季交换计划将把NCCU的本科研究人员带到杜克大学。杜克大学化学系的Wesserhoefer说。Wesserhoefer博士正在探索新的合成方法，将简单的有机分子转化为含有新的碳-碳，碳-氮和碳-氧键的更复杂的分子。通过利用含有金属原子的化合物的新化学，特别是钯，铂和金，Wesserhoefer博士正在开发用于构建复杂的天然和生物活性分子的简单工具，在制造，精细化学品生产以及药物发现和合成领域具有潜在的应用。除了杜克大学的学生，这个研究计划从事本科生从北卡罗来纳州中央大学通过夏季研究交流计划。

This project addresses the development of Pd(II)-, Pt(II)-, and Au(I)-catalyzed processes for the addition of C-, N-, and O-nucleophiles to unactivated olefins. The scope of the Pt-catalyzed alkylation of indoles will be explored, and an effective protocol for the asymmetric cyclization of allenyl indoles will be developed. The Pt-catalyzed hydroamination of alkenyl amines and methodologies for the hydroamination of alkenyl carbamates will also be explored. Additional reactions slated for examination include intramolecular hydroamination of allenes, intermolecular hydroamination of unactivated olefins, Pd-catalyzed cyclization/carboalkoxylation of alkenyl indoles, and Pt-catalyzed hydroalkoxylation of hydroxy olefins. A summer exchange program with North Carolina Central University (NCCU) will bring undergraduate researchers from NCCU to Duke University.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Ross A. Widenhoefer, of the Department of Chemistry at Duke University. Dr. Widenhoefer is exploring new synthetic methods for the conversion of simple organic molecules into more complex molecules containing new carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds. By exploiting the novel chemistry of compounds containing metal atoms, in particular palladium, platinum, and gold, Dr. Widenhoefer is developing simple tools for the construction of complex naturally-occurring and biologically active molecules, with potential applications in the areas of manufacturing, fine chemical production, and pharmaceutical discovery and synthesis. In addition to Duke University students, this research program engages undergraduate students from North Carolina Central University through a summer research exchange program.