MRI: Acquisition of a TOF High Resolution Mass Spectrometer

杜克大学化学系将从主要研究仪器(MRI)项目获得这一奖项，并将获得一台LC-TOF高分辨率质谱仪，用于教学和研究。不同的研究项目将包括：操纵金属催化氧化应激的化学工具，催化氢功能化，用于AGT成像的模块化重组转运体辅助的核传递，自修复聚合物，能量转导机制，新型成像剂的设计，阐明细胞信号通路的化学方法，纤维素体，催化纳米光刻，生物启发的小分子合成，以及多肽抗生素的生物有机机制。质谱仪(MS)用于鉴定样品的化学成分，并通过测量样品中分子组成的质量来确定其纯度。层析是一种分离技术，它先于质谱分析。它将混合物分离成几种化学成分，然后由质谱仪进行分析。这些都是被广泛使用的分析技术，用于识别和量化样品的化学成分。这项收购将通过系内现有的密集研究推广计划以及通过在本科化学实验室使用质谱仪，使本科生受益。

With this award from the Major Research Instrumentation (MRI) program, the Chemistry Department at Duke University will acquire a LC-TOF high resolution mass spectrometer for use in teaching and research. A variety of research projects will be investigated including: Chemical Tools to Manipulate Metal-Catalyzed Oxidative Stress, Catalytic Hydrofunctionalization, Modular Recombinant Transporter-Assisted Nuclear Delivery for AGT Imaging, Self-healing Polymers, Energy Transduction Mechanisms, Design of New Imaging Agents, Chemical Approaches to the Elucidation of Cell Signaling Pathways, the Cellulosome, Catalytic Nanolithography, Biologically-Inspired Small Molecule Synthesis, and Bioorganic Mechanisms of Peptide Antibiotics. Mass spectrometry (MS) is used to identify the chemical composition of a sample and determine its purity by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. Chromatography is an isolation technique that precedes the mass spectrometry analysis. It separates a mixture into its several constituent chemicals which are then analyzed by the mass spectrometer. These are widely used analytical techniques to identify and quantify the chemical composition of a sample. The acquisition will benefit undergraduate chemistry students through existing, intensive research outreach programs in the Department and through utilization of the mass spectrometer in the undergraduate chemistry laboratories.