MRI: Acquisition of a TOF High Resolution Mass Spectrometer

MRI：购买 TOF 高分辨率质谱仪

• 批准号: 0923097
• 负责人: Ross Widenhoefer
• 金额: $ 18.79万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923097&HistoricalAwards=false
• 关键词: MRI; Acquisition; TOF; Resolution; Mass

With this award from the Major Research Instrumentation (MRI) program, the Chemistry Department at Duke University will acquire a LC-TOF high resolution mass spectrometer for use in teaching and research. A variety of research projects will be investigated including: Chemical Tools to Manipulate Metal-Catalyzed Oxidative Stress, Catalytic Hydrofunctionalization, Modular Recombinant Transporter-Assisted Nuclear Delivery for AGT Imaging, Self-healing Polymers, Energy Transduction Mechanisms, Design of New Imaging Agents, Chemical Approaches to the Elucidation of Cell Signaling Pathways, the Cellulosome, Catalytic Nanolithography, Biologically-Inspired Small Molecule Synthesis, and Bioorganic Mechanisms of Peptide Antibiotics. Mass spectrometry (MS) is used to identify the chemical composition of a sample and determine its purity by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. Chromatography is an isolation technique that precedes the mass spectrometry analysis. It separates a mixture into its several constituent chemicals which are then analyzed by the mass spectrometer. These are widely used analytical techniques to identify and quantify the chemical composition of a sample. The acquisition will benefit undergraduate chemistry students through existing, intensive research outreach programs in the Department and through utilization of the mass spectrometer in the undergraduate chemistry laboratories.

凭借主要研究仪器（MRI）计划的这一奖项，杜克大学化学系将获得用于教学和研究的LC-TOF高分辨率质谱仪。 将调查各种研究项目，包括：操纵金属催化氧化应激的化学工具，催化氢官能化，用于AGT成像的模块化重组转运蛋白辅助核递送，自愈聚合物，能量传导机制，新成像剂的设计，阐明细胞信号传导途径的化学方法，纤维素体，催化纳米光刻，生物启发的小分子合成，肽类抗生素的生物有机机制。质谱法（MS）用于鉴定样品的化学成分，并通过测量样品中分子成分的质量来确定其纯度，所述分子成分在被电离并被质谱仪检测之后。 色谱法是一种先于质谱分析的分离技术。 它将混合物分离成几种化学成分，然后由质谱仪进行分析。 这些是广泛使用的分析技术，用于识别和量化样品的化学成分。 此次收购将有利于本科化学学生通过现有的，密集的研究推广计划在部门和通过利用质谱仪在本科化学实验室。