The functional role of octopamine and tyramine during insect behaviour

章鱼胺和酪胺在昆虫行为中的功能作用

• 批准号: 175437324
• 负责人: Professor Dr. Hans-Joachim Pflüger (†)
• 金额: --
• 依托单位: AG Neurobiologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/175437324?language=en
• 关键词: functional; role; octopamine; tyramine; during

In this research proposal the aim is to understand how insect behaviour is orchestrated by biogenic amines, and as an example we shall use the “pair” tyramine/octopamine. Octopamine and tyramine play important roles in modulating motor behaviour and, in general, octopamine changes the whole organism from a more static to a more dynamic state and is involved in aggression, foraging, social behaviour, learning and memory. We shall work with identified or type-characterized neurons and by recording from them study the precise timing of their activity during development and behaviour. In detail we shall firstly study descending tyraminergic/octopaminergic neurons of the brain with respect to their sensory inputs, their patterns of activity, their outputs, in order to reveal their connectivity. Secondly, we shall study tyraminergic/octopaminergic neurons under different behavioural conditions and, thus, reveal their respective tyramine/octopamine ratios which dramatically change during certain behaviours. Thirdly, we would like to study the specific effects of tyramine and octopamine on central networks. Fourthly, as we can identify tyraminergic/octopaminergic neurons and as we know the distribution of octopamine- and tyramine-immunoreactivity in different compartments, we would like to study the release mechanisms of these neurons and the functional differences between type I (motor) and type II (neuromodulatory) terminals including their ultrastructure.

在这项研究计划中，目的是了解昆虫的行为是如何由生物胺编排的，作为一个例子，我们将使用“对”酪胺/章鱼胺。章鱼胺和酪胺在调节运动行为中起重要作用，一般来说，章鱼胺将整个生物体从更静态改变为更动态的状态，并参与攻击，觅食，社会行为，学习和记忆。我们将使用已识别或类型特征化的神经元，并通过记录它们来研究它们在发育和行为过程中活动的精确时间。详细地说，我们将首先研究大脑的下行酪胺能/章鱼胺能神经元的感觉输入、活动模式和输出，以揭示它们的连接性。其次，我们将研究不同行为条件下的酪胺能/章鱼胺能神经元，从而揭示它们各自的酪胺/章鱼胺比率在某些行为中发生显着变化。第三，我们想研究酪胺和章鱼胺对中枢网络的具体影响。第四，由于我们可以识别酪胺能/章鱼胺能神经元，并且我们知道章鱼胺和酪胺免疫反应性在不同隔室中的分布，因此我们想研究这些神经元的释放机制以及I型（运动）和II型（神经调节）终末之间的功能差异，包括它们的超微结构。