Recruitment of octopaminergic neurons in different insect species

不同昆虫物种中八巴胺能神经元的募集

• 批准号: 5413855
• 负责人: Professor Dr. Hans-Joachim Pflüger (†)
• 金额: --
• 依托单位: AG Neurobiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2003-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5413855?language=en
• 关键词: Recruitment; octopaminergic; neurons; different; insect

Octopaminergic dorsal or vental unpaired median (DUM or VUM) neurons occur in all insects, and are involved in modulating neuromuscular transmission and in regulationg energy metabolism of their target tissues. They are diffenentially recruited during various motor behaviors although the extract mechanisms of activation are unknown, in particular no presynaptic neurons are known to make direct synaptic contacts with DUM/VUM neurons. By using a compoarative approach between two orthopteran species, the "primitive" New Zealand weta, the African locust, and an American moth, differences in recruitment of octopaminergic neurons and their adaptations to different behavioral constraints will be studied. In particular, the following questions will be adresses: 1i) how are these neurons recruited in wetas and locusts during diffenrent tibial movements each of which has a different behavioral function, (ii) are different neuronal pathways involved in this recruitment, for example local versus intersegmental activation, or sensory activation versus descending command from motor control areas. (iii) In the moth, recruitment of the same class of neurons will be studies in adults and compared to that of larvae. (iv) It is assumed that during metamorphosis the connectivity of these neurons changes, and that the suboesophageal ganglion as a motor control area is involved in this reorganization. Therefore, neurons in the suboesophageal ganglion that may provide inputs to DUM/VUM neurons will be sought and characterized. (v) In addition, DUM/VUM neurons of the suboesophageal ganglion itself that innervate all major brain areas will be characterized.

章鱼胺能背侧或腹侧未配对中位（DUM或VUM）神经元存在于所有昆虫中，并参与调节神经肌肉传递和调节目标组织的能量代谢。它们在各种运动行为中被不同地募集，尽管激活的提取机制尚不清楚，特别是没有已知的突触前神经元与DUM/VUM神经元进行直接的突触接触。通过比较两种直翅目动物，即“原始”新西兰湿塔、非洲蝗虫和美洲飞蛾，将研究章鱼胺能神经元募集的差异及其对不同行为约束的适应。特别是，以下问题将被解决：1)在不同的胫骨运动中，这些神经元是如何在weas和蝗虫中招募的，每种运动都有不同的行为功能；2)参与这种招募的神经元通路是否不同，例如局部激活与节间激活，或感觉激活与运动控制区域的下行命令。（iii）在蛾体中，将对成虫进行同类神经元的招募研究，并与幼虫进行比较。（iv）据推测，在变态过程中，这些神经元的连通性发生了变化，食道下神经节作为运动控制区参与了这种重组。因此，食管下神经节中可能向DUM/VUM神经元提供输入的神经元将被寻找和表征。(v)此外，将描述支配所有主要脑区的食道下神经节本身的DUM/VUM神经元。