Recruitment and functional activity of tumor-infiltrating CD8+ cytotoxic T cells and CD4+ regulatory T cells

肿瘤浸润 CD8 细胞毒性 T 细胞和 CD4 调节性 T 细胞的募集和功能活性

• 批准号: 175696446
• 负责人: Professor Dr. Ulf Dittmer
• 金额: --
• 依托单位: Institut für Virologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/175696446?language=en
• 关键词: Recruitment; functional; activity; tumor; infiltrating

Immune escape is a common feature of tumor cells, but most mechanisms of escape are unknown. To analyze such mechanisms we will use a mouse model in which the transformation of erythroblasts by a murine retrovirus results in a lethal leukemia. Transformed cells express viral antigens and are recognized by T cells. Tumor-specific cytotoxic T cells (CTLs) that kill transformed target cells are induced during tumor development. However, the cytotoxic function of CTLs is suppressed by regulatory T cells (Tregs), and this suppression results in uncontrolled tumor growth. We will investigate the molecular interplay between tumor cells, CTLs, and Tregs.

免疫逃逸是肿瘤细胞的共同特征，但大多数逃逸机制尚不清楚。为了分析这种机制，我们将使用小鼠模型，其中小鼠逆转录病毒转化成红细胞导致致命的白血病。转化的细胞表达病毒抗原并被T细胞识别。肿瘤特异性细胞毒性T细胞（CTL）杀死转化的靶细胞在肿瘤发展过程中诱导。然而，CTL的细胞毒性功能被调节性T细胞（TCLs）抑制，并且这种抑制导致不受控制的肿瘤生长。我们将研究肿瘤细胞、CTL和Tcls之间的分子相互作用。