SBIR Phase I: Novel Labeling Method for Multicolor Fluorescence in situ Hybridization (FISH) Probes

SBIR 第一阶段：多色荧光原位杂交 (FISH) 探针的新型标记方法

• 批准号: 0610573
• 负责人: Joan Aurich-Costa
• 金额: $ 10万
• 依托单位: ONE CELL SYSTEMS, INC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0610573&HistoricalAwards=false
• 关键词: SBIR; Phase; Novel; Labeling; Method

This Small Business Innovative Research (SBIR) Phase I project aims to develop a novel labeling method for multicolor fluorescence in situ hybridization (FISH) probes that will shorten hybridization time and increase assay sensitivity. The high degree of specificity and accuracy, and the ability to generate rapid results have made FISH the method of choice for identifying chromosomal abnormalities, genetic disease and certain cancers. The proposed labeling method will shorted the hybridization time making FISH analysis more rapid and cost effective without losing the sensitivity required for accurate chromosomal determination.

这项小企业创新研究（SBIR）一期项目旨在开发一种新的多色荧光原位杂交（FISH）探针标记方法，以缩短杂交时间并提高检测灵敏度。高度的特异性和准确性以及产生快速结果的能力使FISH成为鉴定染色体异常、遗传疾病和某些癌症的首选方法。所提出的标记方法将缩短杂交时间，使FISH分析更加快速和经济有效，同时又不会失去准确染色体测定所需的灵敏度。