SBIR Phase I: Surface Light Scattering Spectroscopy for Absorption, Distribution, Metabolism and Excretion (ADME) Drug Screening

这个小型企业创新研究(SBIR)第一阶段项目建议开发非侵入性的表面光散射光谱(SLSS)技术，以表征生物膜并增强对流体界面的了解。与目前的候选药物药代动力学筛选方法相比，SLSS有一个明显的优势：能够快速准确地测量关键的生物物理特征和复杂界面的行为，而不会造成物理干扰。这种方法的成功开发将有助于降低吸收、分配、代谢和排泄(ADME)药物筛选的高昂成本。已经成立了一个跨学科的小组，以评估使用SLSS进行脂质表征的可行性，并检查可靠和准确地确定生物膜特性所需的技术问题和改进。第一阶段使用实验室仪器获得可与发表的文献进行验证的测量结果，包括对血脑屏障研究感兴趣的化合物。第二阶段包括改进先进仪器的设计，以及制造和测试商业原型。

This Small Business Innovative Research (SBIR) Phase I project proposes to develop the non-invasive technique of Surface Light Scattering Spectroscopy (SLSS) to characterize biomembranes and enhance the understanding of fluid interfaces. SLSS promises a distinct advantage over current methods for pharmacokinetics screening of drug candidates: the ability to quickly and accurately measure key biophysical characteristics and behavior of complex interfaces without physical disturbance. Successful development of this approach will contribute to reducing the high cost of Absorption, Distribution, Metabolism,and Excretion (ADME) drug screening. An interdisciplinary team has been formed to assess the feasibility of employing SLSS for lipid characterization and to examine technical issues and refinements needed for robust and accurate determination of biomembrane properties. Phase I uses a laboratory instrument to obtain measurements that can be verified against published literature, including compounds that are of interest to blood-brain barrier studies. Phase II includes refinement of an advanced instrument design and fabrication and testing of a commercial prototype.