A Test of Adaptive Divergence Across Altitudinal Gradients: Population Genomics of Deer Mice

跨海拔梯度的适应性分歧测试：鹿鼠群体基因组学

• 批准号: 0614342
• 负责人: Jay Storz
• 金额: $ 49.2万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0614342&HistoricalAwards=false
• 关键词: Test; Adaptive; Divergence; Across; Altitudinal

One of the main goals of evolutionary biology is to elucidate the role of natural selection in shaping patterns of genetic variation. One especially powerful means of accomplishing this goal involves analyzing DNA sequence variation at genes that underlie fitness-related traits in natural populations. By comparing patterns of DNA variation at such genes with patterns of variation among a random sample of genes in a genome, it should be possible to test predictions about the strength and mode of selection acting on individual genes, and the genomic scale at which selection at one site influences patterns of variation at neighboring sites. The purpose of this study is to use natural populations of the deer mouse, Peromyscus maniculatus, as a model system to investigate the joint effects of selection, recombination, and gene flow in shaping the pattern of DNA sequence variation at hemoglobin genes that underlie physiological adaptation to high altitude. This system provides a rare opportunity to study functional variation at the DNA sequence level that can be related to selection caused by a specific environmental effect.This study will involve training for a postdoc and a graduate student and will include an international research experience in Portugal for all participants.

进化生物学的主要目标之一是阐明自然选择在形成遗传变异模式中的作用。实现这一目标的一个特别有效的方法是分析自然种群中与健康相关的性状的基因的DNA序列变异。通过将这些基因的DNA变异模式与基因组中随机基因样本的变异模式进行比较，就有可能检验关于选择作用于单个基因的强度和模式的预测，以及一个位点的选择影响相邻位点变异模式的基因组规模。本研究的目的是使用自然种群的鹿鼠，Peromyscus maniculatus，作为一个模型系统，以探讨选择，重组和基因流的联合作用，在塑造模式的DNA序列变异血红蛋白基因的生理适应高海拔。 该系统提供了一个难得的机会，研究功能变异的DNA序列水平，可以与选择所造成的一个特定的环境effect.This研究将涉及培训博士后和研究生，并将包括在葡萄牙的国际研究经验，为所有参与者。