Chemical Applications of Vibrational Circular Dichroism Spectroscopy

实验物理化学计划支持南加州大学的Philip Stephens教授和他的学生的研究。 Stephens将进一步开发用于测量和预测振动圆二色性（VCD）光谱的实验和理论方法。 大分子的量子力学计算将扩展到包括溶剂的影响和振动的非谐性。 该研究还将开发用于计算/预测VCD光谱和大分子的构象和绝对构型的方法，包括天然产物，肽，肽模拟物和有机金属络合物。 这项工作有望大大增加无机，有机和生物化学家，无论是在学术界和制药行业的VCD光谱的使用。

The Experimental Physical Chemistry Program supports the research of Professor Philip Stephens and his students at the University of Southern California. Stephens will further develop experimental and theoretical methods for the measurement and prediction of vibrational circular dichroism (VCD) spectra. Quantum-mechanical calculations for large molecules will be extended to include the effects of solvents and the anharmonicities of vibrations. The research also will develop methods for the calculation/prediction of VCD spectra and the conformations and absolute configurations of large molecules, including natural products, peptides, peptide mimetics, and organometallic complexes. This work promises to substantially increase the use of VCD spectroscopy by inorganic, organic and biological chemists, both in academia and in the pharmaceutical industry.