Analytical Applications of Coherent Multidimensional Vibrational Spectroscopy

相干多维振动光谱的分析应用

• 批准号: 0650431
• 负责人: John Wright
• 金额: $ 59万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0650431&HistoricalAwards=false
• 关键词: Analytical; Applications; Coherent; Multidimensional; Vibrational

Professor John Wright of the University of Wisconsin-Madison is supported by the Analytical and Surface Chemistry Program to continue development of the new family of mixed frequency/time domain coherent multidimensional spectroscopies that has been pioneered by his team. The goal is to make these methods practical so they can provide coherent alternatives to conventional electronic and vibrational spectroscopy. These methods potentially have great selectivity and information content. The research team will use their discovery of coherent transfer spectroscopy to explore the relationships between coherent and incoherent energy transfer in molecules as well as directly observing the energy redistribution within a molecule. They will also apply four wave mixing spectroscopies to analysis of peptides and proteins to develop models to probe the structural dynamics of these important molecules, their interactions with each other, and the changes that occur when a protein binds to another protein or DNA molecule. The spectroscopic methods currently used by scientists are often limited by their ability to resolve individual species in complex materials and to establish the relationships between species. The development of these coherent methods will provide new capabilities for resolving specific molecules and for identifying the interactions that connect them. These new methods will have broad impact through important applications throughout science and technology because they directly measure and isolate the intra- and inter-molecular interactions that define how a material such as a protein functions. Prof. Wright is actively engaged in related activities aimed at informing the broader scientific community about the fundamentals underlying these tools, and developing and disseminating active learning methods that deepen student competence and expand diversity in science.

威斯康星大学麦迪逊分校的John Wright教授得到了分析和表面化学项目的支持，继续开发他的团队开创的混合频率/时域相干多维光谱的新系列。我们的目标是使这些方法实用化，从而为传统的电子和振动光谱学提供一致的替代方案。这些方法潜在地具有很大的选择性和信息含量。 该研究小组将利用他们的相干转移光谱的发现来探索分子中相干和非相干能量转移之间的关系，并直接观察分子内的能量再分布。他们还将应用四波混合光谱分析肽和蛋白质，以开发模型来探测这些重要分子的结构动力学，它们之间的相互作用，以及当一种蛋白质与另一种蛋白质或DNA分子结合时发生的变化。 科学家目前使用的光谱方法往往受到其在复杂材料中分辨单个物种和建立物种之间关系的能力的限制。这些连贯方法的开发将为解析特定分子和识别连接它们的相互作用提供新的能力。这些新方法将通过整个科学和技术的重要应用产生广泛的影响，因为它们直接测量和分离分子内和分子间的相互作用，这些相互作用定义了蛋白质等材料的功能。 Wright教授积极参与相关活动，旨在向更广泛的科学界介绍这些工具的基本原理，并开发和传播积极的学习方法，以加深学生的能力，扩大科学的多样性。