Heterocycles as Versatile Synthetic Building Blocks

本项目侧重于开发新的合成方法及其在复杂分子合成中的应用。将研究通过电化学偶联构建环状杂环的方法，通过初始[4C+3C]环加成和开环交叉复分解反应形成饱和杂环的途径，以及卤代环丙烯作为三碳片段的应用。这些方法将被应用于几种天然产物的全合成，包括鸟嘌呤C、三氯草酰A和茴香苷g。有了这个奖项，有机和大分子化学项目正在支持康涅狄格大学药学系的Dennis L. Wright教授的研究。赖特教授的研究工作围绕着使用杂环作为构建块的高效合成方法的发展。该项目对化学和制药行业具有相当重要的意义，因为它可能影响有机分子的制备方式。

This project is focused on the development of new synthetic methods and their applications in complex molecule synthesis. The methodology to construct annulated heterocycles through an electrochemical coupling, a route to saturated heterocycles involving an initial [4C+3C] cycloaddition followed by a ring-opening cross-metathesis reaction, and the application of halocyclopropenes as a three-carbon fragment will be studied. These methods will be applied for the total synthesis of several natural products including erinacine C, tricholomalide A, and phelligridin G. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Dennis L. Wright of the Department of Pharmaceutical Sciences at University of Connecticut. Professor Wright's research efforts revolve around the development of efficient synthetic methods using heterocycles as the building blocks. The project is of considerable significance to the chemical and pharmaceutical industry, as it could impact how organic molecules are prepared.