Heterocycles as Versatile Synthetic Building Blocks

本项目致力于开发新的合成方法及其在复杂分子合成中的应用。将研究通过电化学偶联构建环状杂环化合物的方法、通过初始[4C+3C]环加成和随后的开环交叉易位反应生成饱和杂环化合物的路线，以及卤代环丙烯作为三碳片段的应用。这些方法将用于几种天然产物的全合成，包括芥子碱C、毛蒜素A和赤霉素G。有了这个奖项，有机和高分子化学计划将支持康涅狄格大学药学系的Dennis L.Wright教授的研究。赖特教授的研究工作围绕着以杂环为基础的高效合成方法的开发展开。该项目对化工和制药行业具有相当重要的意义，因为它可能会影响有机分子的制备方式。

This project is focused on the development of new synthetic methods and their applications in complex molecule synthesis. The methodology to construct annulated heterocycles through an electrochemical coupling, a route to saturated heterocycles involving an initial [4C+3C] cycloaddition followed by a ring-opening cross-metathesis reaction, and the application of halocyclopropenes as a three-carbon fragment will be studied. These methods will be applied for the total synthesis of several natural products including erinacine C, tricholomalide A, and phelligridin G. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Dennis L. Wright of the Department of Pharmaceutical Sciences at University of Connecticut. Professor Wright's research efforts revolve around the development of efficient synthetic methods using heterocycles as the building blocks. The project is of considerable significance to the chemical and pharmaceutical industry, as it could impact how organic molecules are prepared.