New Approaches to Catalyst Screening and Development

该项目将进一步开发创新的筛选方法，以促进组合催化研究，并在此过程中探索合成有趣的转化。将研究在上一个资助期内开发的原位酶筛选方法的范围。此外，将研究荧光板阅读器，以提高筛选方法的通量。由此产生的方法将用于研究四种不同的反应类别：过渡金属介导的烯丙基取代，水解乙烯基/丙烯醚分解，膨胀环氧化物水解动力学分解和不对称烯烃二羟基化。通过这个奖项，有机和大分子化学项目支持了内布拉斯加大学林肯分校化学系的David B. Berkowitz教授的研究。Berkowitz教授的研究工作围绕着利用酶作为敏感传感器开发有效的组合文库筛选方法。这种方法可以快速检测大量化合物对有机反应的催化活性。他的研究可能会导致发现新的、有效的催化剂，用于有用的合成转化。

This project will further develop innovative screening methodology to facilitate combinatorial catalysis research, and in so doing, to explore synthetically interesting transformations. The scope of the in situ enzymatic screening methods developed in the last funding period will be studied. In addition, a fluorescence plate reader will be investigated in order to improve the throughput of the screening methods. The resulting methods will be used to study four different reaction classes: transition metal mediated allylic substitution, hydrolytic vinyl/propenyl ether resolution, expanded epoxide hydrolytic kinetic resolution, and asymmetric alkene dihydroxylation. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor David B. Berkowitz of the Department of Chemistry at University of Nebraska-Lincoln. Professor Berkowitz's research efforts revolve around the development of efficient screening methods for combinatorial libraries using enzymes as the sensitive sensors. Such methods allow a large number of compounds to be examined quickly for their catalytic activities for organic reactions. His studies could lead to the discovery of new and efficient catalysts for useful synthetic transformations.