New Approaches to Catalyst Screening and Development

催化剂筛选和开发的新方法

• 批准号: 0616840
• 负责人: David Berkowitz
• 金额: $ 42.3万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0616840&HistoricalAwards=false
• 关键词: New; Approaches; Catalyst; Screening; Development

This project will further develop innovative screening methodology to facilitate combinatorial catalysis research, and in so doing, to explore synthetically interesting transformations. The scope of the in situ enzymatic screening methods developed in the last funding period will be studied. In addition, a fluorescence plate reader will be investigated in order to improve the throughput of the screening methods. The resulting methods will be used to study four different reaction classes: transition metal mediated allylic substitution, hydrolytic vinyl/propenyl ether resolution, expanded epoxide hydrolytic kinetic resolution, and asymmetric alkene dihydroxylation. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor David B. Berkowitz of the Department of Chemistry at University of Nebraska-Lincoln. Professor Berkowitz's research efforts revolve around the development of efficient screening methods for combinatorial libraries using enzymes as the sensitive sensors. Such methods allow a large number of compounds to be examined quickly for their catalytic activities for organic reactions. His studies could lead to the discovery of new and efficient catalysts for useful synthetic transformations.

该项目将进一步发展创新的筛选方法，以促进组合催化研究，并在这样做，探索综合有趣的转变。 将研究上一个资助期开发的原位酶筛选方法的范围。 此外，将研究荧光板读数器，以提高筛选方法的通量。 由此产生的方法将被用来研究四个不同的反应类：过渡金属介导的烯丙基取代，水解乙烯基/丙烯基醚决议，扩大环氧化物水解动力学决议，和不对称烯烃二羟基化。 有了这个奖项，有机和高分子化学计划是支持教授大卫B的研究。内布拉斯加大学林肯分校化学系的Berkowitz说。 Berkowitz教授的研究工作围绕着开发使用酶作为敏感传感器的组合文库的有效筛选方法。 这些方法允许快速检测大量化合物对有机反应的催化活性。 他的研究可能会导致发现新的和有效的催化剂，用于有用的合成转化。