Novel approaches for catalyst recycling in organocatalysis

到目前为止，有机催化的一个显著缺点是使用1到30摩尔%的高催化剂负载来获得高选择性和高生产率。在第一个资助项目期间，这一缺点已被催化剂回收以及简单的工作和产品分离与三个高效的催化剂回收概念的发展所克服。然而，这些使能技术并没有在新的催化合成方法领域以及工艺工程领域得到充分体现。因此，在下一个项目阶段，应将光化学反应等先进的有机催化过程与这些使能技术结合起来，同时优化微反应流化学。除了发展新的有机催化过程及其机理和理论认识外，过程工程方面也将在该项目的早期阶段进行研究。催化剂回收的主要方法将基于可切换的溶剂系统，因为反应发生在均相中，从而保持了均相催化的优点。对聚合离子液体的进一步研究，如扩散实验和反应器实验，有待完成。

A significant disadvantage of organocatalysis so far is the use of high catalyst loadings between 1 and 30 mol% to obtain high selectivities and productivities. Within the first funding project period this drawback has been overcome by catalyst recycling as well as simple work up and product isolation with the development of three efficient catalyst recycling concepts. However, these enabling techniques are not fully reflected in the field of new catalytic synthetic methods as well as in the field of process engineering. Therefore, in the next project period advanced organocatalytic processes such as photochemical reactions should be combined with these enabling techniques by simultaneous optimization with micro reaction flow chemistry. Apart from the development of new organocatalytic processes and their mechanistic and theoretical understanding also the aspect of process engineering will be included and investigated at an early stage of this project. The main approach for catalyst recycling will be based on switchable solvent systems since the reaction takes place in the homogeneous phase and thereby maintaining the advantages of homogeneous catalysis. Further investigations on polymerized ionic liquids such as diffusion experiments and reactor experiments should be completed.