Primordial Germ Cell Determination in Echinoderms

棘皮动物原始生殖细胞的测定

• 批准号: 0620607
• 负责人: Gary Wessel
• 金额: --
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0620607&HistoricalAwards=false
• 关键词: Primordial; Germ; Cell; Determination; Echinoderms

ABSTRACT WESSEL Proposal # IOB-0620607Sexual reproduction requires the formation of specialized cells, called gametes. The precursors of these cells, referred to as primordial germ cells, are determined very early in the life of the organism - as an embryo. In this application Dr. Wessel will examine what molecules are important for primordial germ cell development and determination in the sea urchin embryo. This is an important process for several reasons including that these cells are stem cells and studying this process in the sea urchin may help in our fundamental understanding of stem cell biology. Dr. Wessel will also examine how other echinoderms with different developmental strategies make their primordial germ cells. This comparative study will enable investigators to study how the primordial gems cells arise depending on differences in developmental mechanisms of the embryo. This project will also train graduate and undergraduate students in a wide array of modern experimental techniques. The results will be broadly disseminated in peer reviewed publications and online for K-12 students.

WESSEL提案# IOB-0620607有性生殖需要形成专门的细胞，称为配子。这些细胞的前体，被称为原始生殖细胞，在生物体生命的早期-作为胚胎-被确定。在这个应用程序中，Wessel博士将研究哪些分子对海胆胚胎中的原始生殖细胞发育和决定很重要。这是一个重要的过程，有几个原因，包括这些细胞是干细胞，在海胆中研究这一过程可能有助于我们对干细胞生物学的基本理解。Wessel博士还将研究其他具有不同发育策略的棘皮动物如何形成原始生殖细胞。这项比较研究将使研究人员能够研究原始宝石细胞如何根据胚胎发育机制的差异而产生。该项目还将在广泛的现代实验技术方面培训研究生和本科生。结果将在同行评审的出版物和K-12学生的在线上广泛传播。