ATOL Collaborative Research: Resolving Mammalian Phylogeny with Genomic and Morphological Approaches
ATOL 合作研究:利用基因组和形态学方法解决哺乳动物系统发育问题
基本信息
- 批准号:0629849
- 负责人:
- 金额:$ 60万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-10-01 至 2012-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
AToL: Collaborative Research: Resolving Mammalian Phylogeny with Genomic and Morphological ApproachesNovacek, Michael J., American Museum of Natural History, EF 0629811 Murphy, William J., Texas A & M Research Foundation, EF 0629849 O'Leary, Maureen A., SUNY Stony Brook, EF 0629836 Luo, Zhe-Xi, Carnegie Institute, EF 0629959 Springer, Mark, Univ. California, Riverside, EF 0629860 AbstractOnly a few of the myriad biological groups now thriving on this planet have fossil records that chronicle their evolutionary past. One of these few is Mammalia, known from about 5,000 extant species distributed among 1135 living genera, including our own human lineage, and more than 4,000 extinct genera, a four-to-one ratio of fossil genera to living genera that can hardly be matched elsewhere in the biota. Mammals display a spectacular range in size, form, and adaptations. They are closely linked to human health, welfare, and experience. No tree of all life could be regarded as complete without a comprehensive phylogeny of Mammalia. This conviction has inspired a surge of work in paleontology, comparative anatomy, and molecular biology. Despite these significant gains, many aspects of mammalian phylogeny are unresolved or highly controversial, even at some of the major branching points on the mammalian tree. PIs propose to examine species exemplars for 135 extant families, the majority of some 350 extinct families, and to extend this sample to a generic-level data set of 500 extant and nearly 500 extinct genera for combined analysis of genes and morphology. Their molecular team will continue to sample taxa toward a goal of covering 95% of all living genera outside the murids (rats, mice, and kin) and sciurids (squirrels). For character evidence, PIs plan to sample 30Kb in gene sequences from 34 genes for at least one exemplar of all living families. For the larger generic-level phases of the project, they will sample at least 6Kb of sequence. Morphologists will collect a projected 2,000 characters. Completion of a broad scale phylogeny for mammals will provide a model system in evolutionary and comparative biology with numerous applications in conservation and wildlife management, human health, biomedicine, and other areas. In addition, PIs intend to compile an integrated and image rich database for mammalian characters and convert it into a powerful toolkit for conservation management, education, and outreach through training programs and web resources.
AToL:合作研究:用基因组学和形态学方法解决哺乳动物系统发育问题Novacek,Michael J.,美国自然历史博物馆,EF 0629811 Murphy,William J.,得克萨斯A M研究基金会,EF 0629849 O 'Leary,Maureen A.,纽约州立大学斯托尼布鲁克,0629836罗哲曦,卡内基研究所,0629959施普林格,马克,加州大学滨江分校,0629860 在这个星球上繁衍生息的无数生物群中,只有少数几个有化石记录,可以记录它们的进化史。哺乳动物就是其中之一,它有大约5,000个现存的物种,分布在1135个现存的属中,包括我们自己的人类谱系,还有4,000多个灭绝的属,化石属与现存属的比例是4比1,在生物群的其他地方很难与之匹敌。 哺乳动物在大小、形态和适应性方面表现出惊人的变化。它们与人类的健康、福祉和经验密切相关。如果没有哺乳动物的全面进化史,所有的生命树都不能被认为是完整的。这种信念激发了古生物学、比较解剖学和分子生物学的研究热潮。尽管取得了这些重大进展,但哺乳动物生殖的许多方面尚未解决或极具争议,甚至在哺乳动物树上的一些主要分支点。PI建议检查135个现存的家庭,大部分的350个灭绝的家庭,物种样本,并将此样本扩展到一个属级数据集的500个现存的和近500个灭绝的属的基因和形态的综合分析。他们的分子团队将继续对分类群进行采样,目标是覆盖除鼠科动物(大鼠,小鼠和亲属)和松鼠科动物(松鼠)之外的所有现存属的95%。对于性格证据,PI计划从所有活着的家庭中至少一个样本的34个基因中抽取30 Kb的基因序列。对于项目中较大的通用级阶段,他们将采样至少6 Kb的序列。 形态学家将收集预计2,000个字符。大规模哺乳动物遗传学的完成将为进化和比较生物学提供一个模型系统,在保护和野生动物管理,人类健康,生物医学和其他领域有许多应用。此外,PI打算编译一个综合的和图像丰富的哺乳动物特征数据库,并将其转换为一个强大的工具包,用于保护管理,教育和推广,通过培训计划和网络资源。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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William Murphy其他文献
The Lie algebra structure of the $HH^1$ of the blocks of the sporadic Mathieu groups
- DOI:
- 发表时间:
2021-10 - 期刊:
- 影响因子:0
- 作者:
William Murphy - 通讯作者:
William Murphy
A revised comprehensive inventory of landslides induced by the 2007 Aysén earthquake, Patagonia
- DOI:
10.1007/s10064-024-04057-2 - 发表时间:
2025-02-20 - 期刊:
- 影响因子:4.200
- 作者:
Alejandra Serey;Sergio A. Sepúlveda;William Murphy;Gregory P. De Pascale;David N. Petley - 通讯作者:
David N. Petley
8: MULTIPLE METABOLITIES AND PATHWAYS ARE DYSREGULATED PRIOR TO ONSET OF INTESTINAL INFLAMMATION IN EXPERIMENTAL CROHN'S DISEASE
- DOI:
10.1016/s0016-5085(22)60008-8 - 发表时间:
2022-05-01 - 期刊:
- 影响因子:
- 作者:
Pooja R. Mina;Christopher M. Soto;Atul Dev;Sartajdeep Kahlon;William Murphy;Maneesh Dave - 通讯作者:
Maneesh Dave
Analysis of the fundamental differences between dam-forming landslides and all landslides
成坝型滑坡与所有滑坡之间的根本差异分析
- DOI:
10.1016/j.geomorph.2025.109665 - 发表时间:
2025-04-15 - 期刊:
- 影响因子:3.300
- 作者:
Hang Wu;Mark A. Trigg;William Murphy;Raul Fuentes - 通讯作者:
Raul Fuentes
Outcomes of stereoelectroencephalography exploration at an epilepsy surgery center
癫痫手术中心立体脑电图探索的结果
- DOI:
10.1111/ane.13229 - 发表时间:
2020 - 期刊:
- 影响因子:3.5
- 作者:
J. Peedicail;Amal Almohawes;W. Hader;Y. Starreveld;Shaily Singh;C. Josephson;William Murphy;P. Federico;S. Wiebe;N. Pillay;Y. Agha;N. Jetté;Rey Avendano;Salma Hanna - 通讯作者:
Salma Hanna
William Murphy的其他文献
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{{ truncateString('William Murphy', 18)}}的其他基金
REU Site: Summer Undergraduate Research in Genetics and Genomics (SURGe)
REU 网站:遗传学和基因组学暑期本科生研究 (SURGe)
- 批准号:
2349410 - 财政年份:2024
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
Understanding the Co-Evolution of Phylogenomic Signal, Gene Linkage, and Recombination Rate Through Comparative Genomics
通过比较基因组学了解系统发育信号、基因连锁和重组率的共同进化
- 批准号:
2150664 - 财政年份:2022
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Phylogenomics and the roles of chromosome architecture, recombination and hybridization on phylogenetic accuracy in the cat family (Felidae)
系统发育学以及染色体结构、重组和杂交对猫科(猫科)系统发育准确性的作用
- 批准号:
1753760 - 财政年份:2018
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Collaborative Research: The Genetic and Anatomical Determinants of Olfaction
合作研究:嗅觉的遗传和解剖学决定因素
- 批准号:
1456506 - 财政年份:2015
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
Collaborative Research: Regulators of cellular microenvironment and multiscale osteointegration
合作研究:细胞微环境调节剂和多尺度骨整合
- 批准号:
1105591 - 财政年份:2011
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
Silicate Bioceramic Structure Control on Mesenchymal Stem Cell Proliferation and Differentiation
硅酸盐生物陶瓷结构对间充质干细胞增殖和分化的控制
- 批准号:
0906817 - 财政年份:2009
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
MSc Engineering Geology. Masters Training Grant (MTG) to provide funding for 5 full studentships for two years.
工程地质学硕士。
- 批准号:
NE/H525611/1 - 财政年份:2009
- 资助金额:
$ 60万 - 项目类别:
Training Grant
CAREER: Controlling Soluble Morphogen Gradients in Biomaterials
职业:控制生物材料中的可溶性形态发生梯度
- 批准号:
0745563 - 财政年份:2008
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
Language and Politics in a West African Chiefdom
西非酋长国的语言和政治
- 批准号:
8318245 - 财政年份:1984
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
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