Postdoctoral Research Fellowship in Biological Informatics FY 2006

生物信息学博士后研究奖学金 2006 财年

• 批准号: 0630707
• 负责人: Siobain Duffy
• 金额: $ 12万
• 依托单位: Duffy, Siobain M
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-11-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0630707&HistoricalAwards=false
• 关键词: Postdoctoral; Research; Fellowship; Biological; Informatics

Project Title: "Understanding the Unexpectedly High Mutation Rate and Rapid Evolution of Small DNA Viruses"This project is awarded under the Postdoctoral Research Fellowships in Biological Informatics Program for 2006. The Fellow will uses computational analyses to estimate the substitution rate, study the mutational bias and determine the evolutionary dynamics of small DNA viruses. The project has two aims: (1) determine whether the unexpectedly high mutation rates and intra-host diversity of single-stranded DNA viruses are due to chemical degradation of certain bases of DNA, such as unpaired cytosines, which would result in a high, but biased, substitution rate; and (2) determine the first independent measure of the substitution rate of human papillomaviruses, a small double-stranded DNA pathogen which is thought to have co-diverged with humans during ancient migrations. The research will be carried out in the lab of Edward Holmes at Pennsylvania State University. Training will focus on cutting-edge bioinformatic techniques, and how to study virus evolution through deep evolutionary time. This knowledge, combined with my expertise in experimental evolution, will enable an independent research program integrating in vivo and in silico approaches to virus evolution at a research-oriented university

项目名称：“了解小型DNA病毒出乎意料的高突变率和快速进化”本项目是2006年度生物信息学博士后研究奖学金项目。 该研究员将使用计算分析来估计替代率，研究突变偏差并确定小DNA病毒的进化动力学。该项目有两个目标：（1）确定单链DNA病毒出乎意料的高突变率和宿主内多样性是否是由于DNA的某些碱基（例如未配对的胞嘧啶）的化学降解，这将导致高但有偏差的取代率;以及（2）确定人乳头瘤病毒替代率的第一独立量度，一种小的双链DNA病原体，被认为在古代迁徙过程中与人类共同分化。 这项研究将在宾夕法尼亚州立大学的爱德华·霍姆斯实验室进行。培训将侧重于尖端的生物信息学技术，以及如何通过深层进化时间研究病毒进化。这些知识，加上我在实验进化方面的专长，将使一个独立的研究计划，在一个研究型大学整合体内和计算机方法来病毒进化